Valiloxybate

Valiloxybate

SCHEMBL8125478

CC(C)[C@@H](N)C(=O)OCCCC(=O)O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRP O00591 3/20 0.42
GABRD O14764 3/20 0.42
GABRA1 P14867 3/20 0.42
GABRB1 P18505 3/20 0.42
GABRG2 P18507 3/20 0.42
GABRB3 P28472 3/20 0.42
GABRA5 P31644 3/20 0.42
GABRA3 P34903 3/20 0.42
GABRA2 P47869 3/20 0.42
GABRB2 P47870 3/20 0.42
GABRA4 P48169 3/20 0.42
GABRE P78334 3/20 0.42
GABRA6 Q16445 3/20 0.42
GABRG1 Q8N1C3 3/20 0.42
GABRG3 Q99928 3/20 0.42
GABRQ Q9UN88 3/20 0.42
SLC7A5 Q01650 1/20 0.41
ALDH1A1 P00352 3/20 0.39
ENPEP Q07075 3/20 0.37
LMNA P02545 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Valiloxybate SCHEMBL27165970 1.00 GABRP (0.42) GABRPGABRDGABRA1GABRB1GABRG2
Valiloxybate SCHEMBL3730354 1.00 GABRP (0.42) GABRPGABRDGABRA1GABRB1GABRG2
Valiloxybate SCHEMBL3730350 1.00 GABRP (0.42) GABRPGABRDGABRA1GABRB1GABRG2
Valiloxybate SCHEMBL34468016 0.98 GABRP (0.41) GABRPGABRDGABRA1GABRB1GABRG2
Valiloxybate SCHEMBL34467996 0.96 GABRP (0.39) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7603837 0.94 ALDH1A1 (0.47) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7603840 0.94 ALDH1A1 (0.47) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL27138529 0.94 ALDH1A1 (0.47) GABRPGABRDGABRA1GABRB1GABRG2
Valiloxybate SCHEMBL34467970 0.92 GABRP (0.36) GABRPGABRDGABRA1GABRB1GABRG2
Valiloxybate SCHEMBL34468040 0.90 GABRP (0.35) GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4167971-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2023-04-26 EP claimed
EP-4167966-A1 PHARMACEUTICAL GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2023-04-26 EP claimed
CN-115803017-A Pharmaceutical granulation of water-soluble active pharmaceutical ingredients 凯瑞康宁生物工程有限公司 2023-03-14 CN claimed
CN-115038432-A Controlled release granulation of water soluble active pharmaceutical ingredients 凯瑞康宁生物工程(武汉)有限公司 2022-09-09 CN claimed
US-20220183977-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2022-06-16 US claimed
US-11304906-B2 Controlled release granulations of water-soluble active pharmaceutical ingredients XWPharma Ltd. (KY) 2022-04-19 US claimed
US-20210393537-A1 PHARMACEUTICAL GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2021-12-23 US claimed
US-20210393529-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2021-12-23 US claimed
WO-2021257832-A1 PHARMACEUTICAL GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2021-12-23 WO claimed
WO-2021257886-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2021-12-23 WO claimed
US-10774031-B2 Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof XW LABORATORIES INC. (KY) 2020-09-15 US claimed
US-20200223783-A1 PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF XW LABORATORIES INC. (KY) 2020-07-16 US claimed
US-20250262157-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS XWPharma Ltd. (KY) 2025-08-21 US disclosed
US-12337066-B2 Controlled release granulations of water-soluble active pharmaceutical ingredients XWPharma Ltd. (KY) 2025-06-24 US disclosed
CN-117618393-A Controlled release granulation of water-soluble active pharmaceutical ingredient 凯瑞康宁生物工程(武汉)有限公司 2024-03-01 CN disclosed
CN-115038432-B Controlled release granulation of water-soluble active pharmaceutical ingredient 凯瑞康宁生物工程(武汉)有限公司 2023-12-26 CN disclosed
WO-2017050259-A1 PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF XW LABORATORIES INC. (KY) 2017-03-30 WO disclosed
WO-2017050259-A1 PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF XW LABORATORIES INC. (KY) 2017-03-30 WO disclosed
EP-0988304-A1 NUCLEOSIDES ANALOGUES, SUCH AS ANTIVIRALS INCLUDING INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTASE AND THE DNA POLYMERASE OF HEPATITIS B VIRUS (HBV) MEDIVIR AB (SE) 2000-03-29 EP disclosed
WO-1999009031-A1 NUCLEOSIDES ANALOGUES, SUCH AS ANTIVIRALS INCLUDING INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTASE AND THE DNA POLYMERASE OF HEPATITIS B VIRUS (HBV) MEDIVIR AB (SE) 1999-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12337066-B2 Controlled release granulations of water-soluble active pharmaceutical ingredients GMPS, SI, UGGT1 GABRP 1338/4885GABRD 844/4885GABRA1 1823/4885
US-20210393529-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS GMPS, SI, UGGT1 GABRP 1338/4885GABRD 844/4885GABRA1 1823/4885
US-20250262157-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS GMPS, SI, UGGT1 GABRP 1338/4885GABRD 844/4885GABRA1 1823/4885
US-10774031-B2 Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof GABRB3, GABRB2, GABRB1 GABRP 9/4885GABRD 22/4885GABRA1 26/4885
US-20210393537-A1 PHARMACEUTICAL GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS GMPS, GYS2, SLC18A1 GABRP 504/4885GABRD 549/4885GABRA1 1140/4885
US-20220183977-A1 CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS GMPS, SI, UGGT1 GABRP 1338/4885GABRD 844/4885GABRA1 1823/4885
US-11304906-B2 Controlled release granulations of water-soluble active pharmaceutical ingredients GMPS, SI, UGGT1 GABRP 1338/4885GABRD 844/4885GABRA1 1823/4885
US-20200223783-A1 PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF GABRB3, GABRB2, GABRB1 GABRP 9/4885GABRD 22/4885GABRA1 26/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.