Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | PNLIP | P16233 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909578 | 0.78 | HPGD (0.41) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8910285 | 0.78 | PARP10 (0.44) | GAAALDH1A1KMT2AMAPTPOLB | |
| SCHEMBL8909858 | 0.76 | MAPT (0.30) | KMT2AMAPT | |
| SCHEMBL8148024 | 0.74 | TDP2 (0.40) | NPC1MEN1KMT2AHTTMAPT | |
| SCHEMBL8910407 | 0.72 | BCHE (0.39) | KMT2AHTT | |
| SCHEMBL8155023 | 0.72 | HTT (0.33) | SMN1; SMN2KMT2AHTTMAPT | |
| SCHEMBL8910147 | 0.72 | LMNA (0.31) | LMNAALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL8910392 | 0.71 | CCNB2 (0.32) | LMNAHTTMAPT | |
| SCHEMBL8540291 | 0.70 | MYC (0.33) | ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL8910714 | 0.70 | ALDH1A1 (0.34) | NPC1LMNAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | claimed |
| US-6013807-A | Antitumor tetracyclic compounds | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2000-01-11 | — | — | US | disclosed |
| US-5852204-A | Pyrrolo 3,2-b-!-carbazoles and 1H 1!benzothieno 2,3-f! indoles having anti-tumor activity | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-12-22 | — | — | US | disclosed |
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |