Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL576378 | 0.73 | SLC18A3 (0.45) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL576980 | 0.73 | SLC18A3 (0.45) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL576724 | 0.73 | SLC18A3 (0.45) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL5315718 | 0.72 | CYP1A2 (0.54) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL10532107 | 0.71 | RAB9A (0.54) | MAPTCYP3A4DDB1CRBNCA2 | |
| SCHEMBL5666189 | 0.71 | LMNA (0.39) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL577173 | 0.71 | SLC18A3 (0.42) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL7883065 | 0.70 | MAPT (0.52) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL576866 | 0.69 | SLC18A3 (0.41) | MAPTLMNACYP1A2TP53CYP3A4 | |
| SCHEMBL2396347 | 0.69 | ALDH1A1 (0.42) | MAPTTP53MAPK1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180282275-A1 | New alkynyl-substituted 3-phenylpyrrolidine-2,4-diones and use thereof as herbicides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-10-04 | — | — | US | claimed |
| WO-2017060204-A1 | NEW ALKYNYL-SUBSTITUTED 3-PHENYLPYRROLIDINE-2,4-DIONES AND USE THEREOF AS HERBICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-04-13 | — | — | WO | claimed |
| US-8334300-B2 | C2-phenyl-substituted cyclic ketonols | BAYER AKTIENGESELLSHAFT (DE) | 2012-12-18 | — | — | US | claimed |
| US-20110183849-A1 | C2-PHENYL-SUBSTITUTED CYCLIC KETONOLS | BAYER AKTIENGESELLSCHAFT (DE) | 2011-07-28 | — | — | US | claimed |
| EP-1280770-B1 | C 2? PHENYL-SUBSTITUTED CYCLIC KETO-ENOLS USED AS PESTICIDES AND HERBICIDES | BAYER AG (DE) | 2010-06-23 | — | — | EP | claimed |
| US-20030216260-A1 | C2-phenyl-substituted cyclic keto-enols used as pesticides and herbicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2003-11-20 | — | — | US | claimed |
| EP-1280770-A1 | C 2? PHENYL-SUBSTITUTED CYCLIC KETO-ENOLS USED AS PESTICIDES AND HERBICIDES | Bayer Aktiengesellschaft (DE) | 2003-02-05 | — | — | EP | claimed |
| WO-2001074770-A1 | C2 PHENYL-SUBSTITUTED CYCLIC KETO-ENOLS USED AS PESTICIDES AND HERBICIDES | BAYER CROPSCIENCE AG (DE) | 2001-10-11 | — | — | WO | claimed |
| US-20230059463-A1 | 3-(2-BROMO-4-ALKYNYL-6-ALKOXYPHENYL)-SUBSTITUTED 5-SPIROCYCLOHEXYL-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2023-02-23 | — | — | US | disclosed |
| US-20220386606-A1 | SPECIFICALLY SUBSTITUTED 3-PHENYL-5-SPIROCYCLOPENTYL-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2022-12-08 | — | — | US | disclosed |
| US-20220151230-A1 | SPECIFICALLY SUBSTITUTED 3-(2-HALOGEN-6-ALKYL-4-PROPINYLPHENYL)-3-PYRROLIN-2-ONES AND TO THE USE THEREOF AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2022-05-19 | — | — | US | disclosed |
| US-20220151230-A1 | SPECIFICALLY SUBSTITUTED 3-(2-HALOGEN-6-ALKYL-4-PROPINYLPHENYL)-3-PYRROLIN-2-ONES AND TO THE USE THEREOF AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2022-05-19 | — | — | US | disclosed |
| CN-108349888-B | Novel alkynyl-substituted 3-phenylpyrrolidine-2, 4-diones and their use as herbicides | 拜耳作物科学股份公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-108349888-B | Novel alkynyl-substituted 3-phenylpyrrolidine-2, 4-diones and their use as herbicides | 拜耳作物科学股份公司 | 2022-03-25 | — | — | CN | disclosed |
| WO-1999043649-A1 | ARYLPHENYL-SUBSTITUTED CYCLIC KETO-ENOLS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-09-02 | — | — | WO | disclosed |
| EP-0918775-A1 | PHENYL-SUBSTITUTED CYCLIC KETOENOL | BAYER AG (DE) | 1999-06-02 | — | — | EP | disclosed |
| WO-1999016748-A1 | UTILIZING SPIROCYCLIC PHENYL KETO-ENOLS AS PESTICIDES AND HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-04-08 | — | — | WO | disclosed |
| WO-1998006721-A1 | PHENYL-SUBSTITUTED CYCLIC KETOENOL | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-19 | — | — | WO | disclosed |
| EP-0809629-A1 | 2-PHENYL-SUBSTITUTED HETEROCYCLIC 1,3-KETONOLS AS HERBICIDES AND PESTICIDES | BAYER AG (DE) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025395-A1 | 2-PHENYL-SUBSTITUTED HETEROCYCLIC 1,3-KETONOLS AS HERBICIDES AND PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220386606-A1 | SPECIFICALLY SUBSTITUTED 3-PHENYL-5-SPIROCYCLOPENTYL-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | DDT, HPD, AGPS | MAPT 3960/4885LMNA 4352/4885CYP1A2 145/4885 |
| US-20030216260-A1 | C2-phenyl-substituted cyclic keto-enols used as pesticides and herbicides | PDHX, AKR1C3, AKR1A1 | MAPT 4082/4885LMNA 2316/4885CYP1A2 81/4885 |
| US-20180282275-A1 | New alkynyl-substituted 3-phenylpyrrolidine-2,4-diones and use thereof as herbicides | CBR3, HDHD5, HPD | MAPT 4443/4885LMNA 2562/4885CYP1A2 95/4885 |
| US-20110183849-A1 | C2-PHENYL-SUBSTITUTED CYCLIC KETONOLS | AKR1C3, PDHX, AKR1C2 | MAPT 3712/4885LMNA 1007/4885CYP1A2 88/4885 |
| US-20220151230-A1 | SPECIFICALLY SUBSTITUTED 3-(2-HALOGEN-6-ALKYL-4-PROPINYLPHENYL)-3-PYRROLIN-2-ONES AND TO THE USE THEREOF AS HERBICIDES | DDT, HPD, PFAS | MAPT 4431/4885LMNA 4286/4885CYP1A2 41/4885 |
| US-20230059463-A1 | 3-(2-BROMO-4-ALKYNYL-6-ALKOXYPHENYL)-SUBSTITUTED 5-SPIROCYCLOHEXYL-3-PYRROLIN-2-ONES AND THEIR USE AS HERBICIDES | DDT, BROX, CBR3 | MAPT 4139/4885LMNA 3871/4885CYP1A2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.