Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727011 | 0.84 | LMNA (0.57) | LMNAKDM4EMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL8207163 | 0.83 | ALDH1A1 (0.46) | LMNAKDM4EMAPTHTTALDH1A1 | |
| SCHEMBL8221266 | 0.81 | RAB9A (0.49) | LMNAKDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL8213285 | 0.74 | MAPT (0.45) | KDM4EMAPTCYP1A2PFKFB3POLB | |
| SCHEMBL8215908 | 0.71 | CNR2 (0.36) | LMNAKDM4EMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL8219294 | 0.71 | HPGDS (0.41) | KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL8266779 | 0.70 | MAOB (0.44) | LMNAKDM4EMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL8214695 | 0.69 | ALDH1A1 (0.40) | LMNAKDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL8219508 | 0.69 | LMNA (0.40) | LMNAMAPTSMN1; SMN2HTTPOLB | |
| SCHEMBL8268378 | 0.69 | KDM4E (0.48) | LMNAKDM4EMAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |