Sugi Predict

Sugi Predict / Compounds / SCHEMBL822568

SCHEMBL822568

SCHEMBL822568

O=COc1ccc2c3c(ccc(C(=O)NCCc4ccc(F)cc4)c13)C(=O)N(c1ccccc1)C2=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.44
▸ NPC1 O15118 3/20 0.42
▸ RAB9A P51151 3/20 0.42
▸ POLB P06746 2/20 0.40
▸ SLC6A5 Q9Y345 1/20 0.40
▸ CNR2 P34972 3/20 0.39
▸ CNR1 P21554 1/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ APOBEC3A P31941 1/20 0.38
▸ RECQL P46063 1/20 0.38
▸ CASP6 P55212 1/20 0.38
▸ APOBEC3G Q9HC16 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ PLAAT3 P53816 1/20 0.38
▸ PLAAT5 Q96KN8 1/20 0.38
▸ PLAAT2 Q9NWW9 1/20 0.38
▸ PLAAT4 Q9UL19 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL822751 0.93 CNR2 (0.42) MAPTNPC1RAB9APOLBCNR2
SCHEMBL823206 0.86 MAPT (0.48) MAPTNPC1RAB9APOLBSLC6A5
SCHEMBL822491 0.85 THRB (0.46) MAPTNPC1RAB9APOLBCNR2
SCHEMBL12102581 0.80 THRB (0.45) MAPTNPC1RAB9APOLBCNR2
SCHEMBL822567 0.78 KMT2A (0.42) NPC1RAB9APOLBCNR2KDM4E
SCHEMBL823143 0.78 KDM4E (0.52) MAPTNPC1RAB9APOLBCNR2
SCHEMBL822451 0.76 ALDH1A1 (0.43) NPC1RAB9APOLBCNR2CNR1
SCHEMBL822452 0.72 MEN1 (0.45) MAPTNPC1RAB9APOLBALDH1A1
SCHEMBL823207 0.70 THRB (0.49) MAPTNPC1RAB9APOLBCNR2
SCHEMBL12104600 0.66 THRB (0.47) MAPTNPC1RAB9APOLBCNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8530270-B2 Methods of preparing semiconductive compositions and devices EASTMAN KODAK COMPANY (US) 2013-09-10 — — US disclosed
US-8411489-B2 Semiconducting devices and methods of preparing EASTMAN KODAK COMPANY (US) 2013-04-02 — — US disclosed
US-8314265-B2 Aromatic amic acids or amic esters and compositions EASTMAN KODAK COMPANY (US) 2012-11-20 — — US disclosed
US-20110269967-A1 AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS BANK OF AMERICA, N.A., AS AGENT 2011-11-03 — — US disclosed
US-20110269966-A1 SEMICONDUCTING ARTICLES CITICORP NORTH AMERICA, INC., AS AGENT 2011-11-03 — — US disclosed
US-20110266523-A1 SEMICONDUCTING DEVICES AND METHODS OF PREPARING BANK OF AMERICA, N.A., AS AGENT 2011-11-03 — — US disclosed
US-20110269265-A1 METHODS OF PREPARING SEMICONDUCTIVE COMPOSITIONS AND DEVICES KODAK REALTY INC. 2011-11-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269966-A1 SEMICONDUCTING ARTICLES ALAD, PORCN, DDC MAPT 1981/4885NPC1 2148/4885RAB9A 2482/4885
US-20110269967-A1 AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS DDC, AADAC, MYOC MAPT 1597/4885NPC1 2077/4885RAB9A 1518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.