SCHEMBL822751

SCHEMBL822751

O=COc1ccc2c3c(ccc(C(=O)NCCc4ccccc4)c13)C(=O)N(c1ccccc1)C2=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 2/20 0.42
CNR1 P21554 1/20 0.42
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 3/20 0.41
POLB P06746 1/20 0.41
APOBEC3A P31941 1/20 0.41
RECQL P46063 1/20 0.41
CASP6 P55212 1/20 0.41
APOBEC3G Q9HC16 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
RAB9A P51151 7/20 0.40
NPC1 O15118 6/20 0.40
MAPT P10636 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NR3C1 P04150 1/20 0.40
HDAC2 Q92769 2/20 0.39
HDAC8 Q9BY41 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
HDAC3 O15379 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL822568 0.93 MAPT (0.44) CNR2CNR1KDM4EALDH1A1POLB
SCHEMBL822491 0.91 THRB (0.46) CNR2CNR1POLBRAB9ANPC1
SCHEMBL12102581 0.86 THRB (0.45) CNR2ALDH1A1POLBL3MBTL1RAB9A
SCHEMBL823143 0.84 KDM4E (0.52) CNR2CNR1KDM4EALDH1A1POLB
SCHEMBL822567 0.84 KMT2A (0.42) CNR2KDM4EALDH1A1POLBRAB9A
SCHEMBL822451 0.79 ALDH1A1 (0.43) CNR2CNR1KDM4EALDH1A1POLB
SCHEMBL823206 0.78 MAPT (0.48) CNR2CNR1KDM4EALDH1A1POLB
SCHEMBL822452 0.78 MEN1 (0.45) ALDH1A1POLBRAB9ANPC1MAPT
SCHEMBL823207 0.75 THRB (0.49) CNR2CNR1KDM4EALDH1A1POLB
SCHEMBL12104600 0.71 THRB (0.47) CNR2CNR1KDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8530270-B2 Methods of preparing semiconductive compositions and devices EASTMAN KODAK COMPANY (US) 2013-09-10 US disclosed
US-8411489-B2 Semiconducting devices and methods of preparing EASTMAN KODAK COMPANY (US) 2013-04-02 US disclosed
US-8314265-B2 Aromatic amic acids or amic esters and compositions EASTMAN KODAK COMPANY (US) 2012-11-20 US disclosed
US-20110269967-A1 AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS BANK OF AMERICA, N.A., AS AGENT 2011-11-03 US disclosed
US-20110269265-A1 METHODS OF PREPARING SEMICONDUCTIVE COMPOSITIONS AND DEVICES KODAK REALTY INC. 2011-11-03 US disclosed
US-20110269966-A1 SEMICONDUCTING ARTICLES CITICORP NORTH AMERICA, INC., AS AGENT 2011-11-03 US disclosed
US-20110266523-A1 SEMICONDUCTING DEVICES AND METHODS OF PREPARING BANK OF AMERICA, N.A., AS AGENT 2011-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269966-A1 SEMICONDUCTING ARTICLES ALAD, PORCN, DDC CNR2 2376/4885CNR1 3241/4885KDM4E 1041/4885
US-20110269967-A1 AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS DDC, AADAC, MYOC CNR2 4290/4885CNR1 4579/4885KDM4E 664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.