Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR known ✓ | Q92847 | 17/20 | 0.51 |
| ▸ | TACR1 known ✓ | P25103 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595843 | 0.88 | PPARA (0.41) | GHSRTACR1 | |
| SCHEMBL8161727 | 0.87 | GHSR (0.39) | GHSRTACR1 | |
| SCHEMBL8466975 | 0.86 | GHSR (0.39) | GHSRTACR1 | |
| SCHEMBL7979239 | 0.86 | GHSR (0.39) | GHSRTACR1 | |
| Hydrochloric Acid SCHEMBL8606952 | 0.78 | GHSR (0.32) | GHSR | |
| SCHEMBL8462876 | 0.76 | GHSR (0.39) | GHSR | |
| SCHEMBL8561970 | 0.75 | TACR1 (0.38) | GHSRTACR1 | |
| SCHEMBL8564275 | 0.75 | CTSS (0.49) | GHSRTACR1 | |
| SCHEMBL8150673 | 0.75 | GHSR (0.57) | GHSRTACR1 | |
| SCHEMBL8561651 | 0.73 | TACR1 (0.42) | GHSRTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028196-A | USING INEXPENSIVE AND ENVIRONMENTALLY ACCEPTABLE STARTING MATERIALS REAGENTS AND SOLVENTS, NO CHROMATOGRAPHIC PURIFICATION OF INTERMEDIATE SPIROINDOLINE SULFONAMIDE TO PRODUCE THE STIMULANTS FOR RELEASING SOMATOTROPIN | MERCK & CO., INC. (US) | 2000-02-22 | — | — | US | disclosed |