SCHEMBL824913

SCHEMBL824913

Nc1cccc2occc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.48
TSHR P16473 4/20 0.48
ALDH1A1 P00352 4/20 0.48
HPGD P15428 4/20 0.48
HSD17B10 Q99714 3/20 0.48
TDP1 Q9NUW8 1/20 0.48
MAOA P21397 2/20 0.45
MAOB P27338 2/20 0.45
FTO Q9C0B1 1/20 0.45
KEAP1 Q14145 1/20 0.41
KCNA3 P22001 1/20 0.40
NR4A2 P43354 1/20 0.38
NQO1 P15559 1/20 0.38
FADS1 O60427 1/20 0.37
EED O75530 3/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
ALOX15 P16050 1/20 0.35
CASP1 P29466 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxalic Acid SCHEMBL16467215 0.88 MAOB (0.41) CYP3A4TSHRALDH1A1HPGDHSD17B10
SCHEMBL30578887 0.83 ALDH1A1 (0.52) CYP3A4TSHRALDH1A1HPGDHSD17B10
Propionic Acid SCHEMBL11195372 0.82 MTNR1A (0.41) CYP3A4TSHRALDH1A1HPGDHSD17B10
SCHEMBL19638404 0.81 ALDH1A1 (0.50) CYP3A4TSHRALDH1A1HPGDHSD17B10
Benzofuran SCHEMBL28223437 0.76 ALDH1A1 (0.63) CYP3A4TSHRALDH1A1HPGDHSD17B10
SCHEMBL13947728 0.73 MAOA (0.46) CYP3A4TSHRALDH1A1HPGDHSD17B10
SCHEMBL827237 0.71 MAOA (0.50) TSHRMAOAMAOBFTOKCNA3
SCHEMBL275378 0.71 MAOA (0.45) CYP3A4TSHRALDH1A1HPGDHSD17B10
SCHEMBL788355 0.71 MAOA (0.45) CYP3A4TSHRALDH1A1HPGDHSD17B10
SCHEMBL275377 0.71 MAOA (0.50) CYP3A4TSHRALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289789-A1 REVERSIBLE LYSINE COVALENT MODIFIERS OF CDK2 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. 2025-09-18 US disclosed
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2025-07-03 US disclosed
CN-116217566-B Anti-apoptosis protein BCL-2 inhibitor, pharmaceutical composition and application thereof 杭州和正医药有限公司 2025-05-23 CN disclosed
WO-2025090658-A2 REVERSIBLE LYSINE COVALENT MODIFIERS OF CDK2 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. (US) 2025-05-01 WO disclosed
US-20250034135-A1 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF Hangzhou Healzen Therapeutics Co., Ltd. (CN) 2025-01-30 US disclosed
US-20240400531-A1 HERBICIDAL MALONAMIDES CONTAINING A CONDENSED RING SYSTEM BASF SE (DE) 2024-12-05 US disclosed
US-12145913-B2 Inhibition of Olig2 activity Curtana Pharmaceuticals, Inc. (US) 2024-11-19 US disclosed
EP-4442685-A1 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF Hangzhou HealZen Therapeutics Co., Ltd. (CN) 2024-10-09 EP disclosed
CN-118515595-A Deep blue fluorescent molecule based on 2,2' -bisindole skeleton and preparation method and application thereof 泰州学院 2024-08-20 CN disclosed
EP-4396173-A1 HERBICIDAL MALONAMIDES CONTAINING A CONDENSED RING SYSTEM BASF SE (DE) 2024-07-10 EP disclosed
US-6140331-A FOR TREATING ANXIETY DISORDERS, DEPRESSION, PSYCHOSIS, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, ISCHAEMIC DISEASES, CARDIOVASCULAR DISORDERS, SIDE EFFECTS INDUCED BY CONVENTIONAL ANTIPSYCHOTIC AGENTS AND SENILE DEMENTIA H. LUNDBECK A/S (DK) 2000-10-31 US disclosed
EP-0673375-B1 FUSED BENZO COMPOUNDS LUNDBECK & CO AS H (DK) 1999-02-24 EP disclosed
US-5753661-A TREATMENT OF NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS H. LUNDBECK A/S (DK) 1998-05-19 US disclosed
EP-0812321-A1 PROKINETIC OXADIAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 1997-12-17 EP disclosed
WO-1996026937-A1 PROKINETIC OXADIAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-06 WO disclosed
EP-0673375-A1 FUSED BENZO COMPOUNDS H. LUNDBECK A/S (DK) 1995-09-27 EP disclosed
WO-1994013659-A1 FUSED BENZO COMPOUNDS H. LUNDBECK A/S (DK) 1994-06-23 WO disclosed
EP-0079683-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-05-06 EP disclosed
US-4514211-A HERBICIDES, PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-30 US disclosed
EP-0079683-A2 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-05-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250289789-A1 REVERSIBLE LYSINE COVALENT MODIFIERS OF CDK2 AND USES THEREOF CDK2, CDK20, CDK1 CYP3A4 2478/4885TSHR 2513/4885ALDH1A1 3042/4885
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF CYP3A4 4531/4885TSHR 144/4885ALDH1A1 2560/4885
US-20240400531-A1 HERBICIDAL MALONAMIDES CONTAINING A CONDENSED RING SYSTEM DDT, ME3, ME1 CYP3A4 165/4885TSHR 3945/4885ALDH1A1 1099/4885
US-20250034135-A1 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF BCL2, BAX, BCL2L1 CYP3A4 4495/4885TSHR 4379/4885ALDH1A1 4614/4885
US-12145913-B2 Inhibition of Olig2 activity POU2F2, POU2F1, PLP2 CYP3A4 4823/4885TSHR 4588/4885ALDH1A1 1823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.