Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 6/20 | 0.55 |
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | DRD3 | P35462 | 6/20 | 0.55 |
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628228 | 1.00 | L3MBTL1 (0.59) | L3MBTL1DRD2DRD4DRD3APP | |
| SCHEMBL13925530 | 0.88 | DRD2 (0.59) | L3MBTL1DRD2DRD4DRD3APP | |
| SCHEMBL12585056 | 0.88 | DRD2 (0.59) | L3MBTL1DRD2DRD4DRD3APP | |
| SCHEMBL18475584 | 0.88 | APP (0.74) | L3MBTL1APPALDH1A1NPC1HPGD | |
| SCHEMBL14153966 | 0.88 | APP (0.54) | L3MBTL1DRD2DRD4DRD3APP | |
| SCHEMBL10457449 | 0.87 | APP (0.59) | APPALDH1A1KCNH2 | |
| SCHEMBL22537466 | 0.87 | APP (0.60) | L3MBTL1DRD2DRD4DRD3APP | |
| SCHEMBL20170389 | 0.87 | APP (0.60) | L3MBTL1DRD2DRD4DRD3APP | |
| SCHEMBL313373 | 0.85 | DRD2 (0.64) | L3MBTL1DRD2DRD4DRD3KCNH2 | |
| SCHEMBL5929468 | 0.82 | DRD2 (0.68) | L3MBTL1DRD2DRD4DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020140924-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO AΒ PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | 原子高科股份有限公司 | 2020-07-09 | — | — | WO | disclosed |
| WO-2018132636-A1 | [18F]MALEIMIDE-BASED GLYCOGEN SYNTHASE KINASE-3BETA LIGANDS FOR POSITRON EMISSION TOMOGRAPHY IMAGING AND RADIOSYNTHESIS METHOD | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-07-19 | — | — | WO | disclosed |
| US-9790169-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170233340-A1 | NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2017-08-17 | — | — | US | disclosed |
| US-9714221-B1 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | SANOFI (FR) | 2017-07-25 | — | — | US | disclosed |
| US-20160289171-A1 | IDO INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2016-10-06 | — | — | US | disclosed |
| EP-2338059-B1 | Ligands for aggregated tau molecules | WISTA LAB LTD (SG) | 2015-04-08 | — | — | EP | disclosed |
| US-8969383-B2 | Picolinamide derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2015-03-03 | — | — | US | disclosed |
| US-20140296237-A1 | PICOLINAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2014-10-02 | — | — | US | disclosed |
| US-8658131-B2 | Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2014-02-25 | — | — | US | disclosed |
| US-20110311447-A1 | Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2011-12-22 | — | — | US | disclosed |
| US-20110311447-A1 | Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2011-12-22 | — | — | US | disclosed |
| US-7935674-B2 | Indole derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-05-03 | — | — | US | disclosed |
| US-7935674-B2 | Indole derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-05-03 | — | — | US | disclosed |
| US-20090258921-A1 | INDOLE DERIVATIVES | NOMURA SUMIHIRO | 2009-10-15 | — | — | US | disclosed |
| US-20090258921-A1 | INDOLE DERIVATIVES | NOMURA SUMIHIRO | 2009-10-15 | — | — | US | disclosed |
| US-20090041664-A1 | 5-Pyrrolidinylsulfonyl Isatin Derivatives | UNIVERSITATSKLINIKUM MUNSTER (DE) | 2009-02-12 | — | — | US | disclosed |
| US-20080119422-A1 | Indole Derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-05-22 | — | — | US | disclosed |
| US-20080119422-A1 | Indole Derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-05-22 | — | — | US | disclosed |
| WO-2006009653-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258921-A1 | INDOLE DERIVATIVES | IDO1, TPH1, NAT1 | L3MBTL1 2915/4885DRD2 35/4885DRD4 61/4885 |
| US-20110311447-A1 | Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand | SIGMAR1, TMEM97, OPRM1 | L3MBTL1 3333/4885DRD2 25/4885DRD4 68/4885 |
| US-20140296237-A1 | PICOLINAMIDE DERIVATIVES AS TTX-S BLOCKERS | CACNA1G, SCN3A, SCN5A | L3MBTL1 3282/4885DRD2 2311/4885DRD4 3130/4885 |
| US-20090041664-A1 | 5-Pyrrolidinylsulfonyl Isatin Derivatives | CASP5, CTSZ, CTSS | L3MBTL1 3157/4885DRD2 2515/4885DRD4 3346/4885 |
| US-20160289171-A1 | IDO INHIBITORS | IDO1, IDO2, INMT | L3MBTL1 3687/4885DRD2 3470/4885DRD4 3330/4885 |
| US-20080119422-A1 | Indole Derivatives | IDO1, TPH1, NAT1 | L3MBTL1 2915/4885DRD2 35/4885DRD4 61/4885 |
| US-20170233340-A1 | NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | CYP19A1, ESR1, ESR2 | L3MBTL1 4657/4885DRD2 1097/4885DRD4 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.