Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.48 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP8 | P22894 | 6/20 | 0.43 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963666 | 0.91 | ALDH1A1 (0.45) | MMP2MMP9LMNAPOLBBCHE | |
| SCHEMBL13480198 | 0.88 | MMP2 (0.47) | MMP2MMP9MMP8MMP3MMP12 | |
| SCHEMBL8319573 | 0.85 | MMP2 (0.44) | MMP2MMP9MMP8MMP3MMP12 | |
| SCHEMBL3164298 | 0.84 | LMNA (0.41) | MMP2MMP9LMNAPOLBBCHE | |
| SCHEMBL13201342 | 0.82 | MMP2 (0.52) | MMP2MMP9MMP8MMP3MMP12 | |
| SCHEMBL8320621 | 0.80 | POLB (0.60) | MMP2MMP9MMP12LMNAPOLB | |
| SCHEMBL8320651 | 0.80 | MMP9 (0.62) | MMP2MMP9MMP8MMP3MMP12 | |
| SCHEMBL16298354 | 0.79 | MMP2 (0.49) | MMP2MMP9MMP8MMP3MMP12 | |
| SCHEMBL13201330 | 0.79 | MMP8 (0.52) | MMP2MMP9MMP8MMP3MMP12 | |
| SCHEMBL13480199 | 0.79 | MMP2 (0.49) | MMP2MMP9MMP8MMP3MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |