Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 2/20 | 0.44 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.40 |
| ▸ | TLR4 known ✓ | O00206 | 1/20 | 0.40 |
| ▸ | SELP | P16109 | 8/20 | 0.51 |
| ▸ | SELL | P14151 | 2/20 | 0.46 |
| ▸ | VEGFA | P15692 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335411 | 1.00 | SELP (0.51) | SELPSELLVEGFAFGF1CA2 | |
| SCHEMBL258089 | 0.91 | SELP (0.57) | SELPSELLVEGFAFGF1TLR4 | |
| SCHEMBL8331511 | 0.89 | GAA (0.42) | SELPSELLVEGFACA2TLR4 | |
| SCHEMBL8331515 | 0.89 | GAA (0.42) | SELPSELLVEGFACA2TLR4 | |
| SCHEMBL8331963 | 0.88 | SELP (0.55) | SELPSELLVEGFAFGF1 | |
| SCHEMBL8332237 | 0.86 | FGF1 (0.51) | SELPSELLVEGFAFGF1 | |
| SCHEMBL8335818 | 0.84 | SELP (0.49) | SELPVEGFAFGF1CA2GAA | |
| SCHEMBL8335828 | 0.84 | SELP (0.49) | SELPVEGFAFGF1CA2GAA | |
| SCHEMBL8333368 | 0.80 | SELP (0.66) | SELPSELLVEGFAFGF1 | |
| SCHEMBL258055 | 0.80 | TLR4 (0.53) | SELPSELLVEGFATLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869460-A | ANTIINFLAMMATORY AGENTS | SANWA KAGUKU KENKYUSHO CO., LTD. (JP) | 1999-02-09 | — | — | US | disclosed |
| EP-0771815-A1 | Sulfated and phosphated saccharide derivatives, process for the preparation of the same and use thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1997-05-07 | — | — | EP | disclosed |