SCHEMBL8340214

SCHEMBL8340214

O=C(OCc1ccc(COC(=O)C2=C(c3ccccc3)C(=O)c3ccccc3C2=O)cc1)C1=C(c2ccccc2)C(=O)c2ccccc2C1=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.56
LMNA P02545 5/20 0.56
SMN1; SMN2 Q16637 5/20 0.56
KMT2A Q03164 5/20 0.56
ALDH1A1 P00352 4/20 0.56
MEN1 O00255 4/20 0.56
NPSR1 Q6W5P4 4/20 0.56
NPC1 O15118 4/20 0.56
RAB9A P51151 4/20 0.56
TDP1 Q9NUW8 4/20 0.56
HSP90AA1 P07900 3/20 0.56
HTT P42858 3/20 0.56
HKDC1 Q2TB90 2/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
KDM4E B2RXH2 2/20 0.56
MAPK1 P28482 2/20 0.56
MPI P34949 2/20 0.56
TP53 P04637 1/20 0.56
HSP90AB1 P08238 1/20 0.56
FGFR1 P11362 5/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445362 0.97 ALDH1A1 (0.56) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL21470361 0.93 ALDH1A1 (0.54) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL21470357 0.93 MAPT (0.57) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL13986150 0.89 RAB9A (0.52) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL17969781 0.84 ALDH1A1 (0.78) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL15827661 0.82 NPSR1 (0.56) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL13679127 0.82 NPSR1 (0.56) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL21470359 0.79 L3MBTL1 (0.48) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL17969780 0.78 FGFR1 (0.88) MAPTLMNASMN1; SMN2KMT2AALDH1A1
SCHEMBL17969760 0.78 NPSR1 (0.58) MAPTLMNASMN1; SMN2KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7468230-B2 Wet-developing electrophotographic photoconductor and wet-developing image KYOCERA MITA CORPORATION (JP) 2008-12-23 US disclosed
US-7468230-B2 Wet-developing electrophotographic photoconductor and wet-developing image KYOCERA MITA CORPORATION (JP) 2008-12-23 US disclosed
US-5977389-A Naphthoquinone derivative MITA INDUSTRIAL CO., LTD. (JP) 1999-11-02 US disclosed
EP-0863123-A1 Naphthoquinone derivative and electrophotosensitive material using the same MITA INDUSTRIAL CO. LTD. (JP) 1998-09-09 EP disclosed