Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 1/20 | 0.41 |
| ▸ | SELE | P16581 | 4/20 | 0.51 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.51 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.51 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.51 |
| ▸ | SELL | P14151 | 3/20 | 0.47 |
| ▸ | SELP | P16109 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MDK | P21741 | 4/20 | 0.42 |
| ▸ | BMP2 | P12643 | 3/20 | 0.41 |
| ▸ | VEGFA | P15692 | 3/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.41 |
| ▸ | SHH | Q15465 | 2/20 | 0.41 |
| ▸ | IFNG | P01579 | 2/20 | 0.41 |
| ▸ | PF4 | P02776 | 1/20 | 0.41 |
| ▸ | CCL2 | P13500 | 1/20 | 0.41 |
| ▸ | BMP6 | P22004 | 1/20 | 0.41 |
| ▸ | CCL11 | P51671 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | SELPLG | Q14242 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399869 | 0.95 | LGALS8 (0.53) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8397629 | 0.94 | LGALS8 (0.51) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8401261 | 0.92 | LGALS8 (0.53) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8398295 | 0.91 | SELE (0.51) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8398183 | 0.91 | SELE (0.52) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8403298 | 0.91 | VEGFA (0.49) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8594065 | 0.91 | VEGFA (0.49) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8397776 | 0.90 | SELE (0.51) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8398135 | 0.89 | LGALS8 (0.52) | SELELGALS8LGALS3LGALS4SELL | |
| SCHEMBL8401597 | 0.89 | SELE (0.51) | SELELGALS8LGALS3LGALS4SELL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874411-A | ANTIINFLAMMATORY | GLYCOMED INCORPORATED (US) | 1999-02-23 | — | — | US | disclosed |