SCHEMBL8416902

SCHEMBL8416902

CC(=O)CNS(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.63
ALDH1A1 P00352 8/20 0.61
LMNA P02545 3/20 0.55
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
MMP1 P03956 1/20 0.55
MMP2 P08253 1/20 0.55
MMP9 P14780 1/20 0.55
MMP8 P22894 1/20 0.55
MMP13 P45452 1/20 0.55
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
HTT P42858 1/20 0.54
POLB P06746 1/20 0.53
CA12 O43570 2/20 0.53
CA9 Q16790 2/20 0.53
GBA1 P04062 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
ATM Q13315 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2627764 0.86 ALDH1A1 (0.68) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL760439 0.85 MMP1 (0.67) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL11509059 0.85 SMN1; SMN2 (0.56) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL6619767 0.84 MEP1B (0.62) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL7090406 0.84 CA2 (0.73) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL4859243 0.84 ALDH1A1 (0.59) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL4859251 0.84 ALDH1A1 (0.61) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL1997197 0.84 ALDH1A1 (0.59) SMN1; SMN2ALDH1A1LMNACA1CA2
SCHEMBL10788040 0.83 MMP1 (0.59) SMN1; SMN2ALDH1A1LMNAMMP1MMP2
SCHEMBL10153991 0.82 SMN1; SMN2 (0.64) SMN1; SMN2ALDH1A1LMNACA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239745-A1 METHOD FOR SYNTHESIZING BILIRUBIN Bilix Co., Ltd. (KR) 2024-07-18 US disclosed
US-20230321016-A1 COMBINATION THERAPY FOR TREATING CANCER GONGWIN BIOPHARM CO., LTD (TW) 2023-10-12 US disclosed
US-11752118-B2 Method for treating melanoma GONGWIN BIOPHARM CO., LTD (TW) 2023-09-12 US disclosed
US-11752160-B2 Method for reducing fat by administering benzenesulfonamide compositions GONGWIN BIOPHARM CO., LTD (TW) 2023-09-12 US disclosed
WO-2023018215-A1 METHOD FOR SYNTHESIZING BILIRUBIN 주식회사 빌릭스 2023-02-16 WO disclosed
US-9782370-B2 Pharmaceutical compositions of benzenesulfonamide derivatives for treatment of adenoid cystic carcinoma Gongwin Biopharm Holdings Co., Ltd. (KY) 2017-10-10 US disclosed
US-20170172951-A1 NOVEL PHARMACEUTICAL COMPOSITIONS OF BENZENESULFONAMIDE DERIVATIVES FOR TREATMENT OF ADENOID CYSTIC CARCINOMA GONGWIN BIOPHARM CO., LTD. (TAIWAN) (TW) 2017-06-22 US disclosed
US-8895552-B2 Cyclic amide derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2014-11-25 US disclosed
US-20130217692-A1 CYCLIC AMIDE DERIVATIVE DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2013-08-22 US disclosed
US-20100137283-A1 INHIBITORS OF THE HIV INTEGRASE ENZYME PFIZER INC 2010-06-03 US disclosed
US-7692014-B2 Inhibitors of the HIV integrase enzyme PFIZER, INC. (US) 2010-04-06 US disclosed
US-20090170846-A1 INHIBITORS OF THE HIV INTEGRASE ENZYME PFIZER INC 2009-07-02 US disclosed
US-7468375-B2 Inhibitors of the HIV integrase enzyme PFIZER INC. (US) 2008-12-23 US disclosed
US-20070232644-A1 1-(2,4-difluorobenzyl)-N-hydroxy-3-{[3-(methylsulfonyl)pyrrolidin-1-yl]methyl}-1H-pyrrolo[2,3-c]pyridine-5-carboxamide;acquired immunodeficiency syndrome (\"AIDS\"), and AIDS related complex (\"ARC\") PFIZER INC. 2007-10-04 US disclosed
US-20070099915-A1 INHIBITORS OF THE HIV INTEGRASE ENZYME PFIZER INC. 2007-05-03 US disclosed
US-5990353-A DEMETALLIZING AN ARYLSULFONAMIDE ALKALI METAL SALT WITH AN AROMATIC ISOCYANATE COMPOUND IN AT LEAST ONE SOLVENT; USE AS A COLOR DEVELOPER FOR A THERMAL RECORDING MATERIAL WITH IMPROVED OIL RESISTANCE AND NONPLASTICIZED YAMAMOTO CHEMICALS, INC. (JP) 1999-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170172951-A1 NOVEL PHARMACEUTICAL COMPOSITIONS OF BENZENESULFONAMIDE DERIVATIVES FOR TREATMENT OF ADENOID CYSTIC CARCINOMA ABCD3, CFTR, ADSL SMN1; SMN2 4396/4885ALDH1A1 1243/4885LMNA 2336/4885
US-20070099915-A1 INHIBITORS OF THE HIV INTEGRASE ENZYME IMPDH1, INTS9, TYMP SMN1; SMN2 4080/4885ALDH1A1 437/4885LMNA 3259/4885
US-11752160-B2 Method for reducing fat by administering benzenesulfonamide compositions LIPE, FABP4, LIPA SMN1; SMN2 2584/4885ALDH1A1 728/4885LMNA 920/4885
US-20090170846-A1 INHIBITORS OF THE HIV INTEGRASE ENZYME IMPDH1, IMPA1, TYMP SMN1; SMN2 3999/4885ALDH1A1 406/4885LMNA 3075/4885
US-20070232644-A1 1-(2,4-difluorobenzyl)-N-hydroxy-3-{[3-(methylsulfonyl)pyrrolidin-1-yl]methyl}-1H-pyrrolo[2,3-c]pyridine-5-carboxamide;acquired immunodeficiency syndrome (\"AIDS\"), and AIDS related complex (\"ARC\") AP1M1, AP1G1, AP3B1 SMN1; SMN2 2557/4885ALDH1A1 1652/4885LMNA 4064/4885
US-20230321016-A1 COMBINATION THERAPY FOR TREATING CANCER TP53, MCL1, TOP2B SMN1; SMN2 1941/4885ALDH1A1 381/4885LMNA 2924/4885
US-11752118-B2 Method for treating melanoma TYR, MITF, BRAF SMN1; SMN2 742/4885ALDH1A1 528/4885LMNA 2154/4885
US-20130217692-A1 CYCLIC AMIDE DERIVATIVE HDAC10, H1-10, H1-0 SMN1; SMN2 2704/4885ALDH1A1 538/4885LMNA 1477/4885
US-20240239745-A1 METHOD FOR SYNTHESIZING BILIRUBIN CYP7A1, UGT1A3, UGT1A1 SMN1; SMN2 3177/4885ALDH1A1 225/4885LMNA 1887/4885
US-20100137283-A1 INHIBITORS OF THE HIV INTEGRASE ENZYME IMPDH1, INTS9, TYMP SMN1; SMN2 4080/4885ALDH1A1 437/4885LMNA 3259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.