Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 13/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917349 | 0.80 | NFE2L2 (0.52) | NFE2L2HSD11B1SLC40A1SLC22A12 | |
| SCHEMBL31590466 | 0.80 | NFE2L2 (0.52) | NFE2L2HSD11B1SLC40A1SLC22A12 | |
| SCHEMBL2704725 | 0.80 | NFE2L2 (0.52) | NFE2L2HSD11B1SLC40A1SLC22A12 | |
| SCHEMBL8430567 | 0.80 | NFE2L2 (0.52) | NFE2L2HSD11B1SLC40A1SLC22A12 | |
| SCHEMBL8430463 | 0.79 | NFE2L2 (0.51) | NFE2L2HSD11B1SLC40A1SLC22A12 | |
| Hydrochloric Acid SCHEMBL27792294 | 0.79 | NFE2L2 (0.51) | NFE2L2HSD11B1SLC40A1SLC22A12 | |
| SCHEMBL10361387 | 0.73 | NFE2L2 (0.47) | NFE2L2HSD11B1SLC40A1SLC22A12 | |
| SCHEMBL31315864 | 0.73 | MAPK1 (0.39) | NFE2L2 | |
| SCHEMBL5489278 | 0.71 | LMNA (0.52) | NFE2L2HSD11B1SLC22A12 | |
| SCHEMBL14645410 | 0.71 | GAA (0.45) | NFE2L2SLC40A1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526849-B1 | Substituted N-Fluoropyridiniumsulfonate, intermediates therefor and preparation processes thereof | DAIKIN IND LTD (JP) | 1999-12-01 | — | — | EP | disclosed |
| US-5374732-A | Chemical intermediates as fluorination agents | DAIKIN INDUSTRIES, LTD. (JP) | 1994-12-20 | — | — | US | disclosed |
| EP-0526849-A1 | Novel substituted N-Fluoropyridiniumsulfonate, intermediates therefor and preparation processes thereof | DAIKIN INDUSTRIES, LTD. (JP) | 1993-02-10 | — | — | EP | disclosed |