Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344836 | 0.94 | DRD2 (0.44) | DRD2BACE1LMNACHRM2HTR1A | |
| SCHEMBL4672786 | 0.84 | HRH4 (0.58) | DRD2LMNACHRM2HTR1AADRA2A | |
| SCHEMBL31098228 | 0.84 | DRD2 (0.58) | DRD2BACE1LMNACHRM2HTR1A | |
| SCHEMBL1568889 | 0.83 | DRD2 (0.56) | DRD2BACE1LMNACHRM2HTR1A | |
| SCHEMBL11505754 | 0.82 | TRPA1 (0.41) | DRD2BACE1LMNACHRM2HTR1A | |
| SCHEMBL8251675 | 0.81 | HRH4 (0.46) | DRD2LMNACHRM2HTR1AADRA2A | |
| SCHEMBL21761445 | 0.81 | ALDH1A1 (0.46) | DRD2BACE1LMNACHRM2HTR1A | |
| SCHEMBL5057241 | 0.81 | HRH4 (0.43) | DRD2LMNACHRM2HTR1AADRA2A | |
| SCHEMBL11559842 | 0.79 | ALDH1A1 (0.43) | DRD2BACE1LMNACHRM2HTR1A | |
| SCHEMBL20036412 | 0.78 | DRD2 (0.36) | DRD2BACE1LMNACHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 212 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120136813-A | Deuterium-labeled quetiapine fumarate isotope compound, preparation method thereof and food detection method | 曼哈格(上海)生物科技有限公司 | 2025-06-13 | — | — | CN | claimed |
| US-8389716-B2 | Process for the synthesis of quetiapine | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2013-03-05 | — | — | US | claimed |
| US-8048876-B2 | Process for preparing quetiapine and quetiapine fumarate | MEDICHEM S.A. (ES) | 2011-11-01 | — | — | US | claimed |
| US-20110118460-A1 | PROCESS FOR THE SYNTHESIS OF QUETIAPINE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2011-05-19 | — | — | US | claimed |
| US-20090076262-A1 | PROCESS FOR PREPARING QUETIAPINE AND QUETIAPINE FUMARATE | MEDICHEM, S.A. (ES) | 2009-03-19 | — | — | US | claimed |
| WO-2008152434-A1 | SYNTHESIS FOR THE PREPARATION OF QUETIAPINE | RICHTER GEDEON NYRT. (HU) | 2008-12-18 | — | — | WO | claimed |
| WO-2006135544-A1 | SYNTHESIS OF 11-(4[-(2-HYDROXYETHOXY)ETHYL]-PIPERAZINYL)-DIBENZO[b,f][1,4]THIAZEPINE AND ITS FUMARATE SALT | CAMBREX CHARLES CITY, INC. (US) | 2006-12-21 | — | — | WO | claimed |
| US-20060276641-A1 | Process for preparing quetiapine fumarate | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2006-12-07 | — | — | US | claimed |
| US-20060063927-A1 | Processes for preparing quetiapine and salts thereof | CHEMAGIS LTD. (IL) | 2006-03-23 | — | — | US | claimed |
| CN-120136813-A | Deuterium-labeled quetiapine fumarate isotope compound, preparation method thereof and food detection method | 曼哈格(上海)生物科技有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-120136813-A | Deuterium-labeled quetiapine fumarate isotope compound, preparation method thereof and food detection method | 曼哈格(上海)生物科技有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-114181172-B | Efficient preparation method of quetiapine fumarate | 浙江苏泊尔制药有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-114671829-B | Heterodiad taking indenone and dibenzoazepine as parent nucleus and hydrochloride thereof, preparation method and application thereof | 合肥工业大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-114181172-A | Efficient preparation method of quetiapine fumarate | 浙江苏泊尔制药有限公司 | 2022-03-15 | — | — | CN | disclosed |
| EP-1602650-A1 | Method for the preparation of quetiapine by reductive N-alkylation of 11-Piperazinodibenzo(B,F) (1,4)Thioazepin with an aldehyde | Celon Pharma Sp. z o.o. (PL) | 2005-12-07 | — | — | EP | disclosed |
| EP-0282236-B1 | PROCESS FOR THE PREPARATION OF A THIAZEPINE COMPOUND | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-11 | — | — | EP | disclosed |
| EP-0240228-B1 | THIAZEPINE COMPOUNDS | ICI AMERICAS INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4879288-A | Novel dibenzothiazepine antipsychotic | ICI AMERICAS INC. (US) | 1989-11-07 | — | — | US | disclosed |
| EP-0282236-A1 | Process for the preparation of a thiazepine compound | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-14 | — | — | EP | disclosed |
| EP-0240228-A1 | Thiazepine compounds | ICI AMERICAS INC. (US) | 1987-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063927-A1 | Processes for preparing quetiapine and salts thereof | CYP3A5, QDPR, CYP4Z1 | DRD2 33/4885BACE1 416/4885LMNA 3978/4885 |
| US-20060276641-A1 | Process for preparing quetiapine fumarate | SDHA, SDHB, FH | DRD2 626/4885BACE1 674/4885LMNA 1329/4885 |
| US-20110118460-A1 | PROCESS FOR THE SYNTHESIS OF QUETIAPINE | CYP4F11, MAOB, CYP2F1 | DRD2 216/4885BACE1 566/4885LMNA 3750/4885 |
| US-20090076262-A1 | PROCESS FOR PREPARING QUETIAPINE AND QUETIAPINE FUMARATE | CYP2F1, FH, FAH | DRD2 616/4885BACE1 898/4885LMNA 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.