Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10179821 | 0.81 | NR3C1 (0.39) | PTGS2NR3C1PGRNR3C2AR | |
| SCHEMBL877284 | 0.79 | AHR (0.43) | PTGS2NR3C1PGRNR3C2AR | |
| SCHEMBL10179498 | 0.79 | HTR6 (0.44) | PTGS2HTR6NR3C1PGRNR3C2 | |
| SCHEMBL10179278 | 0.74 | ALDH1A1 (0.43) | — | |
| SCHEMBL2537652 | 0.73 | AHR (0.50) | NR3C1PGRARCYP2D6SLC6A2 | |
| SCHEMBL10179358 | 0.72 | NR3C1 (0.41) | PTGS2NR3C1PGRNR3C2AR | |
| SCHEMBL1757934 | 0.72 | MAPK1 (0.36) | PTGS2 | |
| SCHEMBL987448 | 0.72 | IKBKB (0.43) | PTGS2IKBKBCHUK | |
| SCHEMBL1394068 | 0.72 | TNF (0.42) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL794596 | 0.70 | TNF (0.44) | HTR6CYP2D6SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190192510-A1 | GPR119 AGONIST | NIPPON CHEMIPHAR CO., LTD. (JP) | 2019-06-27 | — | — | US | disclosed |
| US-9000175-B2 | Bicyclic GPR119 modulators | LUPIN LIMITED (IN) | 2015-04-07 | — | — | US | disclosed |
| EP-2643311-A1 | BICYCLIC GPR119 MODULATORS | Lupin Limited (IN) | 2013-10-02 | — | — | EP | disclosed |
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2013-09-19 | — | — | US | disclosed |
| CN-102971304-A | GPR119 agonists | NIPPON CHEMIPHAR CO | 2013-03-13 | — | — | CN | disclosed |
| EP-2532656-A1 | GPR119 AGONIST | Nippon Chemiphar Co., Ltd. (JP) | 2012-12-12 | — | — | EP | disclosed |
| US-20120245344-A1 | GPR119 AGONIST | NIPPON CHEMIPHAR CO., LTD. (JP) | 2012-09-27 | — | — | US | disclosed |
| EP-2474540-A1 | GPR119 AGONIST | Nippon Chemiphar Co., Ltd. (JP) | 2012-07-11 | — | — | EP | disclosed |
| WO-2012069917-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190192510-A1 | GPR119 AGONIST | GPR119, GPR4, GPR27 | PTGS2 2743/4885HTR6 445/4885NR3C1 185/4885 |
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | GPR119, GPR180, GPBAR1 | PTGS2 492/4885HTR6 302/4885NR3C1 139/4885 |
| US-20120245344-A1 | GPR119 AGONIST | GPR119, GPR4, GPR55 | PTGS2 2391/4885HTR6 446/4885NR3C1 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.