Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 13/20 | 0.42 |
| ▸ | CDK2 | P24941 | 12/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554229 | 0.96 | CDK9 (0.42) | CDK9CDK2CCNT1CCNE1CCNE2 | |
| SCHEMBL8557954 | 0.91 | RXRA (0.47) | CDK9CDK2CCNT1RXRACA12 | |
| SCHEMBL8557664 | 0.90 | L3MBTL1 (0.43) | RXRASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL8560882 | 0.89 | MAPT (0.43) | RXRACA12CA1CA2CA9 | |
| SCHEMBL8559713 | 0.87 | FABP1 (0.38) | RXRASMN1; SMN2 | |
| SCHEMBL8560601 | 0.87 | ALOX5AP (0.41) | CA12CA1CA2CA9 | |
| SCHEMBL8559802 | 0.87 | RXRA (0.49) | CDK9CDK2CCNT1RXRACA12 | |
| SCHEMBL7507985 | 0.86 | CA2 (0.46) | CDK9CDK2CCNT1CCNE1CCNE2 | |
| SCHEMBL8559042 | 0.86 | L3MBTL1 (0.43) | RXRASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL8556320 | 0.86 | GRM2 (0.42) | RXRACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |