Sugi Predict

Sugi Predict / Compounds / SCHEMBL861646

SCHEMBL861646

SCHEMBL861646

C=CCN[C@@H](CCCCN)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ FOLH1 Q04609 1/20 0.49
▸ GSR P00390 1/20 0.44
▸ RNPEP Q9H4A4 1/20 0.43
▸ SLC6A5 Q9Y345 1/20 0.42
▸ MMP2 P08253 1/20 0.40
▸ MMP9 P14780 1/20 0.40
▸ GGT1 P19440 1/20 0.40
▸ CPB2 Q96IY4 11/20 0.40
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ TLR2 O60603 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29666181 1.00 FOLH1 (0.49) FOLH1GSRRNPEPSLC6A5MMP2
SCHEMBL861645 1.00 FOLH1 (0.49) FOLH1GSRRNPEPSLC6A5MMP2
SCHEMBL1062835 0.95 FOLH1 (0.42) FOLH1GSRRNPEPSLC6A5MMP2
SCHEMBL20586820 0.95 FOLH1 (0.42) FOLH1GSRRNPEPSLC6A5MMP2
SCHEMBL1062834 0.95 FOLH1 (0.42) FOLH1GSRRNPEPSLC6A5MMP2
SCHEMBL30787971 0.87 GGT1 (0.43) FOLH1GSRRNPEPGGT1
SCHEMBL45766 0.83 FOLH1 (0.49) FOLH1GSRRNPEPSLC6A5MMP2
SCHEMBL6676701 0.83 FOLH1 (0.49) FOLH1GSRRNPEPSLC6A5MMP2
SCHEMBL11217895 0.83 ALDH1A1 (0.51) SLC6A5
Hydrochloric Acid SCHEMBL15923088 0.81 FOLH1 (0.47) FOLH1GSRRNPEPSLC6A5MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1297826-A1 Nasal pharmaceutical compositions containing a NK-2 antagonist Menarini Ricerche S.p.A. (IT) 2003-04-02 — — EP claimed
US-12358948-B2 Neurotensinergic agonists and methods of using same preventing or treating pain SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) 2025-07-15 — — US disclosed
EP-3728304-B1 SOLID PHASE SYNTHESIS OF ACYLATED PEPTIDES BACHEM HOLDING AG (CH) 2025-02-12 — — EP disclosed
US-11591366-B2 Macrocyclic compounds and methods of preventing or treating pain SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) 2023-02-28 — — US disclosed
US-20220168383-A1 NEUROTENSINERGIC AGONISTS AND METHODS OF USING SAME PREVENTING OR TREATING PAIN SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) 2022-06-02 — — US disclosed
EP-3921331-A1 NEUROTENSINERGIC AGONISTS AND METHODS OF USING SAME PREVENTING OR TREATING PAIN Socpra Sciences Santé Et Humaines S.E.C. (CA) 2021-12-15 — — EP disclosed
CN-113677692-A Neurotensin agonists and methods of preventing or treating pain using the same 健康与人类科学公司 2021-11-19 — — CN disclosed
US-20210188979-A1 Therapeutic Nanoparticles Comprising A Therapeutic Agent And Methods of Making and Using Same PFIZER INC. (US) 2021-06-24 — — US disclosed
WO-2020160685-A1 NEUROTENSINERGIC AGONISTS AND METHODS OF USING SAME PREVENTING OR TREATING PAIN SOCPRA Sciences Sante et Humaines S.E.C. (CA) 2020-08-13 — — WO disclosed
CN-111263659-A Supramolecular filamentous assemblies for protein purification 约翰霍普金斯大学 2020-06-09 — — CN disclosed
US-20100068286-A1 Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same PFIZER INC. 2010-03-18 — — US disclosed
EP-2162540-A2 COMPOSITIONS AND METHODS FOR PRODUCING BIOACTIVE FUSION PROTEINS Amgen Inc. (US) 2010-03-17 — — EP disclosed
WO-2010005721-A2 DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME BIND BIOSCIENCES, INC. (US) 2010-01-14 — — WO disclosed
WO-2010005723-A2 DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME BIND BIOSCIENCES, INC. (US) 2010-01-14 — — WO disclosed
WO-2008153745-A2 COMPOSITIONS AND METHODS FOR PRODUCING BIOACTIVE FUSION PROTEINS AMGEN INC. (US) 2008-12-18 — — WO disclosed
WO-2008105759-A1 METHODS FOR SYNTHESIS OF MODIFIED PEPTIDES ARGOLYN BIOSCIENCE, INC. (US) 2008-09-04 — — WO disclosed
CN-1591183-A Image recording material and planographic printing plate FUJI PHOTO FILM CO LTD (JP) 2005-03-09 — — CN disclosed
EP-1297826-A1 Nasal pharmaceutical compositions containing a NK-2 antagonist Menarini Ricerche S.p.A. (IT) 2003-04-02 — — EP disclosed
US-5240913-A Polypeptide anticoagulants BIOGEN, INC. (US) 1993-08-31 — — US disclosed
CN-1072337-A SKIN CARE CREAM DAILY CHEMICAL PLANT SUZHOU RU (CN) 1993-05-26 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11591366-B2 Macrocyclic compounds and methods of preventing or treating pain COX15, ACHE, TRPV1 FOLH1 1583/4885GSR 253/4885RNPEP 2720/4885
US-20210188979-A1 Therapeutic Nanoparticles Comprising A Therapeutic Agent And Methods of Making and Using Same CD47, CD274, PDCD1 FOLH1 8/4885GSR 3136/4885RNPEP 1298/4885
US-12358948-B2 Neurotensinergic agonists and methods of using same preventing or treating pain VIP, NTSR2, VIPR2 FOLH1 609/4885GSR 670/4885RNPEP 1803/4885
US-20100068286-A1 Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same LDHA, LDHB, LPXN FOLH1 177/4885GSR 1936/4885RNPEP 2015/4885
US-20220168383-A1 NEUROTENSINERGIC AGONISTS AND METHODS OF USING SAME PREVENTING OR TREATING PAIN VIP, NTSR2, VIPR2 FOLH1 609/4885GSR 670/4885RNPEP 1803/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.