Tetraxetan

Tetraxetan

SCHEMBL861961

Nc1ccc(N)cc1.O=C(O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 1/20 0.49
HSD17B10 Q99714 1/20 0.47
S1PR1 P21453 1/20 0.43
MAPT P10636 3/20 0.41
KDM4E B2RXH2 2/20 0.41
RAD52 P43351 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
GAA P10253 1/20 0.41
GFER P55789 1/20 0.41
HIF1A Q16665 1/20 0.41
SLC22A6 Q4U2R8 1/20 0.41
SLC22A8 Q8TCC7 1/20 0.41
LMNA P02545 1/20 0.41
EGLN1 Q9GZT9 1/20 0.41
ALDH1A1 P00352 2/20 0.41
SIGMAR1 Q99720 1/20 0.40
POLB P06746 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13723844 0.89 MAPT (0.59) HSD17B10S1PR1MAPTKDM4ERAD52
SCHEMBL18872669 0.89 LMNA (0.59) SLC6A9MAPTLMNAALDH1A1SIGMAR1
SCHEMBL16656260 0.89 LMNA (0.59) SLC6A9MAPTLMNAALDH1A1SIGMAR1
SCHEMBL8655258 0.89 LMNA (0.59) SLC6A9MAPTLMNAALDH1A1SIGMAR1
SCHEMBL6550220 0.86 SIGMAR1 (0.60) S1PR1MAPTSMN1; SMN2ALDH1A1SIGMAR1
SCHEMBL23876498 0.85 SLC6A9 (0.39) SLC6A9HSD17B10S1PR1MAPTKDM4E
SCHEMBL15499796 0.85 NPC1 (0.56) MAPTKDM4ERAD52SMN1; SMN2GAA
SCHEMBL17076742 0.83 MAPT (0.53) HSD17B10S1PR1MAPTKDM4ERAD52
SCHEMBL15652766 0.82 SLC18A3 (0.48) S1PR1SIGMAR1
SCHEMBL3897416 0.82 ALDH1A1 (0.64) KDM4ELMNAALDH1A1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6911457-B2 Imaging probes and methods for using the probes in diagnostic imaging processes and other imaging processes to determine physiological functions. CARBOMER, INC. (US) 2005-06-28 US claimed
US-20030207823-A1 Novel diabetes imaging probes CARBOMER, INC. 2003-11-06 US claimed
US-12486302-B2 Somatostatin receptor antagonist compounds and methods of using the same CDRD VENTURES INC. (CA) 2025-12-02 US disclosed
US-20220112242-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2022-04-14 US disclosed
EP-2433963-A1 Receptor (SSTR2)-selective somatostatin antagonists The Salk Institute for Biological Studies (US) 2012-03-28 EP disclosed
US-20110269683-A1 RECEPTOR(SSTR2)-SELECTIVE SOMATOSTATIN ANTAGONISTS UNIVERSITY HOSPITAL BASEL 2011-11-03 US disclosed
EP-2383289-A1 Receptor (SSTR2)-selective somatostatin antagonists The Salk Institute for Biological Studies (US) 2011-11-02 EP disclosed
US-7960342-B2 Side effect reduction; block receptor function so they can be used in therapy; labeled with radioactive iodine; drug screening THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2011-06-14 US disclosed
US-7192570-B2 Compositions of somatostatin analogues UNIVERSITY OF BERN (CH) 2007-03-20 US disclosed
EP-1419178-B1 SOMATOSTATIN ANALOGUES AND THEIR USE SOMATOSTATIN ANALOGUES BINDING TO ALL SOMATOSTATIN RECEPTOR AND THEIR USE UNIV BERN (CH) 2006-05-31 EP disclosed
US-7048907-B2 Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products BIOPHYSICS ASSAY LABORATORY, INC. (US) 2006-05-23 US disclosed
US-20060067881-A1 Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products BIOPHYSICS ASSAY LABORATORY, INC. 2006-03-30 US disclosed
US-6911457-B2 Imaging probes and methods for using the probes in diagnostic imaging processes and other imaging processes to determine physiological functions. CARBOMER, INC. (US) 2005-06-28 US disclosed
US-20040242842-A1 Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use UNIVERSITY OF BERN (CH) 2004-12-02 US disclosed
US-20030207823-A1 Novel diabetes imaging probes CARBOMER, INC. 2003-11-06 US disclosed
US-20030059368-A1 Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products BIOPAL, INC. 2003-03-27 US disclosed
EP-1283216-A1 Somatostatin analogues binding to all somatostatin receptor subtypes and their use Mallinckrodt Inc. (US) 2003-02-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12486302-B2 Somatostatin receptor antagonist compounds and methods of using the same GPR119, SSTR5, SSTR2 SLC6A9 2411/4885HSD17B10 1848/4885S1PR1 182/4885
US-20220112242-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME GPR119, SSTR5, SSTR2 SLC6A9 2411/4885HSD17B10 1848/4885S1PR1 182/4885
US-20040242842-A1 Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use SSTR5, NPY5R, GLP1R SLC6A9 1343/4885HSD17B10 2830/4885S1PR1 2617/4885
US-20110269683-A1 RECEPTOR(SSTR2)-SELECTIVE SOMATOSTATIN ANTAGONISTS SSTR5, SSTR4, SSTR3 SLC6A9 1251/4885HSD17B10 2885/4885S1PR1 165/4885
US-20030207823-A1 Novel diabetes imaging probes IAPP, GPR119, DPP4 SLC6A9 1863/4885HSD17B10 633/4885S1PR1 837/4885
US-20060067881-A1 Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products ATP6V1B1, REN, GLS SLC6A9 595/4885HSD17B10 4172/4885S1PR1 3971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.