SCHEMBL8804692

SCHEMBL8804692

CONc1cn([C@]2(C)O[C@H](CO)[C@@H](O)[C@H]2O)c(=S)[nH]c1=O

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PYGB P11216 3/20 0.32
PYGL P06737 2/20 0.32
PYGM P11217 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28326624 0.89 PYGM (0.34) PYGM
SCHEMBL27900812 0.88 PYGM (0.33) PYGBPYGLPYGM
SCHEMBL513129 0.83 PYGL (0.31) PYGBPYGLPYGM
SCHEMBL4849542 0.83 KDM4E (0.33) PYGBPYGLPYGM
SCHEMBL5954319 0.82 TK1 (0.37) PYGBPYGLPYGM
SCHEMBL27900813 0.81 PYGB (0.34) PYGBPYGLPYGM
SCHEMBL28973925 0.78 PYGB (0.33) PYGBPYGLPYGM
SCHEMBL7262195 0.77 PYGM (0.36) PYGM
SCHEMBL7872134 0.75 PYGB (0.31) PYGBPYGM
SCHEMBL6028061 0.75 SLC28A1 (0.42) PYGBPYGLPYGM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102203253-B Multi-exon skipping compositions for DMD SAREPTA THERAPEUTICS, INC. (US) 2016-04-06 CN disclosed
CN-104661664-A Chiral control WAVE LIFE SCIENCES PTY LTD 2015-05-27 CN disclosed
CN-104245958-A Detection of nucleic acids SPEEDX PTY LTD 2014-12-24 CN disclosed
EP-0506892-B1 BORONATED NUCLEOSIDES BORON BIOLOG INC (US) 1997-10-08 EP disclosed
US-5659027-A BORONATED AT RING NITROGEN OF PURINE OR PYRIMIDINE BASE OR AT AN AMINO SUBSTITUENT OF THE NUCLEOSIDE SUGAR UNIVERSITY OF NORTH CAROLINA (US) 1997-08-19 US disclosed
EP-0649411-A4 BORONATED COMPOUNDS. BORON BIOLOG INC (US) 1995-07-12 EP disclosed
EP-0649411-A1 BORONATED COMPOUNDS BORON BIOLOGICALS, INC. (US) 1995-04-26 EP disclosed
US-5362732-A Purine and pyrimidine bases N-boronated with-BH2CN,-BH3, -BF3,-BH2COOR or -BH2C/O/NHR, where R is H or alkyl; pharmaceutical comprising antihyperlipidemic, antiinflammatory or analgesic boronated compound and carrier UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1994-11-08 US disclosed
WO-1994001413-A1 BORONATED COMPOUNDS BORON BIOLOGICALS, INC. (US) 1994-01-20 WO disclosed
EP-0506892-A4 BORONATED NUCLEOSIDES 1993-03-31 EP disclosed
US-5177198-A PROCESS FOR PREPARING OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES UNIVERSITY OF N.C. AT CHAPEL HILL (US) 1993-01-05 US disclosed
EP-0506892-A1 BORONATED NUCLEOSIDES. BORON BIOLOG INC (US) 1992-10-07 EP disclosed
US-5130302-A Antiinflammatory agents or antitumor agents BORON BILOGICALS, INC. (US) 1992-07-14 US disclosed
WO-1991009048-A1 BORONATED NUCLEOSIDES BARON BIOLOGICALS, INC. (US) 1991-06-27 WO disclosed
WO-1991008213-A1 OLIGORIBONUCLOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES BORON BIOLOGICALS, INC. (US) 1991-06-13 WO disclosed