Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964088 | 0.94 | OPRD1 (0.37) | PRMT5CYP2D6OPRM1OPRD1CHEK2 | |
| SCHEMBL8963516 | 0.89 | CHEK2 (0.42) | PRMT5CYP2D6OPRM1OPRD1MGAM | |
| SCHEMBL8963580 | 0.89 | PRMT5 (0.40) | PRMT5SLC6A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL8963783 | 0.88 | PRMT5 (0.40) | PRMT5SLC6A2SLC6A4OPRD1 | |
| SCHEMBL8963737 | 0.87 | OPRM1 (0.38) | PRMT5OPRM1OPRD1GAAHTR1A | |
| SCHEMBL8963820 | 0.87 | HDAC6 (0.34) | OPRM1OPRD1CHEK2 | |
| SCHEMBL8963675 | 0.84 | TACR1 (0.36) | MAPK14PRMT5OPRM1OPRD1CHEK2 | |
| SCHEMBL8963679 | 0.83 | MEN1 (0.42) | PRMT5SLC6A2SLC6A4OPRD1 | |
| SCHEMBL8964138 | 0.81 | SLC6A4 (0.38) | PRMT5SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL8963650 | 0.80 | CHEK2 (0.40) | PRMT5SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514800-A | CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1996-05-07 | — | — | US | disclosed |