Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964034 | 0.89 | SLC6A2 (0.36) | TNKSPARP1TNKS2PRMT5SLC6A2 | |
| SCHEMBL8963505 | 0.89 | SLC6A2 (0.41) | TNKSPARP1TNKS2PRMT5SLC6A2 | |
| SCHEMBL8963527 | 0.88 | PRMT5 (0.32) | TNKSPARP1TNKS2PRMT5DRD2 | |
| SCHEMBL8963580 | 0.87 | PRMT5 (0.40) | TNKSPARP1TNKS2PRMT5SLC6A2 | |
| Hydrochloric Acid SCHEMBL8963783 | 0.86 | PRMT5 (0.40) | TNKSPARP1TNKS2PRMT5SLC6A2 | |
| SCHEMBL8964088 | 0.85 | OPRD1 (0.37) | TNKSPARP1TNKS2PRMT5ADRB1 | |
| SCHEMBL8963675 | 0.82 | TACR1 (0.36) | TNKSPARP1TNKS2PRMT5TACR1 | |
| SCHEMBL8963679 | 0.81 | MEN1 (0.42) | PRMT5SLC6A2SLC6A4DRD2DRD4 | |
| SCHEMBL8963637 | 0.80 | MAPK13 (0.37) | PRMT5SLC6A2SLC6A4CYP2D6KCNH2 | |
| SCHEMBL8963516 | 0.80 | CHEK2 (0.42) | PRMT5ADRB1CYP2D6HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514800-A | CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1996-05-07 | — | — | US | disclosed |