Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2
The experimentally established mechanism targets of Cytarabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.45 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.45 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | TK1 | P04183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cytarabine SCHEMBL8144526 | 0.96 | LMNA (0.47) | LMNASMN1; SMN2THRBMTORMDM2 | |
| Cytidine SCHEMBL4468985 | 0.89 | LMNA (0.65) | LMNASMN1; SMN2THRBMTORMDM2 | |
| Floxuridine SCHEMBL407748 | 0.87 | LMNA (0.68) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| Cytidine SCHEMBL27461239 | 0.84 | LMNA (0.69) | LMNASMN1; SMN2THRBMTORMDM2 | |
| Doxribtimine SCHEMBL6518312 | 0.80 | LMNA (0.62) | LMNASMN1; SMN2THRBMTORMDM2 | |
| Doxribtimine SCHEMBL787714 | 0.80 | LMNA (0.62) | LMNASMN1; SMN2THRBMTORMDM2 | |
| Doxribtimine SCHEMBL28210016 | 0.78 | TK1 (0.52) | LMNASMN1; SMN2TK1 | |
| Deoxyuridine SCHEMBL28056346 | 0.77 | DUT (0.47) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| Cytidine SCHEMBL574822 | 0.77 | LMNA (0.67) | LMNATHRBMTORMDM2NCOA1 | |
| 5-Fluorouridine SCHEMBL4390962 | 0.77 | LMNA (0.83) | LMNASMN1; SMN2P2RY6ALOX12ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514364-A | Non-lethal methods for conditioning a recipient for bone marrow transplantation | UNIVERSITY OF PITTSBURGH (US) | 1996-05-07 | — | — | US | disclosed |