Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.48 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.48 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.48 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.48 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.48 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.38 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.38 |
| ▸ | HTR4 known ✓ | Q13639 | 2/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8985215 | 1.00 | ADRA2A (0.48) | ADRA2AADRA2BHTR3AADRA2CSLC6A4 | |
| SCHEMBL9570757 | 0.94 | ADRA2A (0.53) | ADRA2AADRA2BHTR3AADRA2CSLC6A4 | |
| Ramosetron SCHEMBL9052281 | 0.72 | HTR3A (0.89) | ADRA2AADRA2BHTR3AADRA2CSLC6A4 | |
| Ramosetron SCHEMBL9052272 | 0.72 | HTR3A (0.75) | ADRA2AADRA2BHTR3AADRA2CSLC6A4 | |
| Ramosetron SCHEMBL9048659 | 0.72 | HTR3A (0.75) | ADRA2AADRA2BHTR3AADRA2CSLC6A4 | |
| Ramosetron SCHEMBL9048670 | 0.72 | HTR3A (0.89) | ADRA2AADRA2BHTR3AADRA2CSLC6A4 | |
| SCHEMBL27249969 | 0.72 | NPSR1 (0.59) | ADRA2AADRA2BHTR3AADRA2CSLC6A4 | |
| SCHEMBL11233424 | 0.70 | POLB (0.62) | POLBRAB9ALMNANPSR1NR4A2 | |
| Maleic Acid SCHEMBL7313437 | 0.68 | HTR3E (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7313443 | 0.68 | HTR3E (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547961-A | USING TETRAHYDROIMIDAZOPYRIDINE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-08-20 | — | — | US | disclosed |
| EP-0532754-A1 | TETRAHYDROIMIDAZOPYRIDINE DERIVATIVE OR ITS SALT | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-03-24 | — | — | EP | disclosed |