Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9115693 | 0.86 | FFAR1 (0.46) | ALDH1A1LMNANPSR1MAPTCNR1 | |
| SCHEMBL9054157 | 0.82 | DRD2 (0.41) | ALDH1A1LMNANPSR1KEAP1MCOLN3 | |
| SCHEMBL8544314 | 0.81 | MAPT (0.54) | ALDH1A1MAPTHTTCDK2KDM4E | |
| SCHEMBL9053622 | 0.80 | DRD2 (0.50) | LMNAMAPTKDM4EDRD2DRD3 | |
| SCHEMBL9053039 | 0.78 | PGR (0.51) | ALDH1A1LMNAMAPTKEAP1KDM4E | |
| SCHEMBL9051914 | 0.78 | MAPT (0.42) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL21494230 | 0.76 | CDK2 (0.48) | NPSR1MAPTCDK2 | |
| SCHEMBL8545748 | 0.75 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTKDM4EDRD2 | |
| SCHEMBL9053693 | 0.75 | CYP11B1 (0.44) | LMNAMAPTKDM4EDRD2DRD3 | |
| SCHEMBL9053598 | 0.75 | SIRT2 (0.46) | LMNAMAPTKDM4EDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734378-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016674-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1995-06-22 | — | — | WO | disclosed |