Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | BRD1 | O95696 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053039 | 0.87 | PGR (0.51) | DRD2DRD3PGRMAPTKDM4E | |
| SCHEMBL9053622 | 0.87 | DRD2 (0.50) | DRD2DRD3PGRMAPTKDM4E | |
| SCHEMBL9115693 | 0.86 | FFAR1 (0.46) | DRD2DRD3PGRMAPTKDM4E | |
| SCHEMBL9051914 | 0.86 | MAPT (0.42) | SIRT2DRD2DRD3PGRMAPT | |
| SCHEMBL8544314 | 0.81 | MAPT (0.54) | DRD2DRD3MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL9053693 | 0.79 | CYP11B1 (0.44) | DRD2DRD3MAPTKDM4ELMNA | |
| SCHEMBL9053185 | 0.78 | MAPT (0.50) | DRD2DRD3PGRMAPTKDM4E | |
| SCHEMBL9054157 | 0.78 | DRD2 (0.41) | DRD2DRD3LMNA | |
| SCHEMBL8545748 | 0.75 | ALDH1A1 (0.54) | DRD2DRD3MAPTKDM4ELMNA | |
| SCHEMBL9053358 | 0.75 | PSEN1 (0.43) | DRD2DRD3MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734378-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016674-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1995-06-22 | — | — | WO | disclosed |