Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499727 | 0.91 | ESR1 (0.47) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL9797716 | 0.89 | NQO1 (0.42) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL16952712 | 0.87 | NQO1 (0.46) | NQO1TSHRTDP1CYP3A4AHR | |
| SCHEMBL4880339 | 0.85 | NQO1 (0.44) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL5740806 | 0.85 | NQO1 (0.44) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL16953037 | 0.85 | NQO1 (0.39) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL16960727 | 0.85 | NQO1 (0.39) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL16952562 | 0.85 | NQO1 (0.39) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL457601 | 0.84 | NQO1 (0.42) | NQO1TSHRTDP1TP53CYP3A4 | |
| SCHEMBL10858288 | 0.84 | TP53 (0.53) | NQO1TSHRTDP1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 390 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3324974-B1 | COMPOUNDS, COMPOSITIONS, METHODS FOR TREATING DISEASES, AND METHODS FOR PREPARING COMPOUNDS | UNIV LOUISVILLE RES FOUND INC (US) | 2022-06-08 | — | — | EP | claimed |
| US-11312690-B2 | Compounds, compositions, methods for treating diseases, and methods for preparing compounds | UNIVERSITY OF LOUSVILLE RESEARCH FOUNDATION, INC. (US) | 2022-04-26 | — | — | US | claimed |
| US-11208379-B2 | Compounds, compositions, methods for treating diseases, and methods for preparing compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2021-12-28 | — | — | US | claimed |
| US-20210355064-A1 | METHODS RELATED TO CARBON DIOXIDE | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2021-11-18 | — | — | US | claimed |
| CN-113444125-A | Novel phosphoramidite ligand, preparation method thereof and application thereof in asymmetric carbonylation reaction | 西北大学 | 2021-09-28 | — | — | CN | claimed |
| US-11078148-B2 | Methods for the reduction of carbon dioxide | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2021-08-03 | — | — | US | claimed |
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2021-05-13 | — | — | US | claimed |
| EP-3038621-B1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RES INSTITUTE (US) | 2020-12-02 | — | — | EP | claimed |
| US-20200277248-A1 | METHODS FOR THE REDUCTION OF CARBON DIOXIDE | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2020-09-03 | — | — | US | claimed |
| US-20200079742-A1 | COMPOUNDS, COMPOSITIONS, METHODS FOR TREATING DISEASES, AND METHODS FOR PREPARING COMPOUNDS | UNIVERSITY OF LOUSVILLE RESEARCH FOUNDATION, INC. (US) | 2020-03-12 | — | — | US | claimed |
| US-20080223444-A1 | Perylene Charge-Transport Materials, Methods of Fabrication Thereof, and Methods of Use Thereof | GEORGIA TECH RESEARCH CORPORATION | 2008-09-18 | — | — | US | claimed |
| WO-2006127024-A1 | REAGENTS AND METHODS FOR LABELING TERMINAL OLEFINS | EISAI CO. LTD. (JP) | 2006-11-30 | — | — | WO | claimed |
| WO-2006093965-A2 | CORONENE CHARGE-TRANSPORT MATERIALS, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF | GEORGIA TECH RESEARCH CORPORATION (US) | 2006-09-08 | — | — | WO | claimed |
| US-20060045846-A1 | Reagents and methods for labeling terminal olefins | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-03-02 | — | — | US | claimed |
| WO-2005124453-A2 | PERYLENE CHARGE-TRANSPORT MATERIALS, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF | GEORGIA TECH RESEARCH CORPORATION (US) | 2005-12-29 | — | — | WO | claimed |
| US-6124478-A | Methods of using 1,2-dioxetanes and kits therefore | TROPIX, INC. (US) | 2000-09-26 | — | — | US | claimed |
| EP-0536896-B1 | Imidazolidyl macrolides having immunosuppressive activity | MERCK & CO INC (US) | 1997-12-17 | — | — | EP | claimed |
| US-5247076-A | IMIDAZOLIDYL MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1993-09-21 | — | — | US | claimed |
| EP-0536896-A1 | Imidazolidyl macrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1993-04-14 | — | — | EP | claimed |
| WO-1993005059-A1 | IMIDAZOLIDYL MACROLIDES | MERCK & CO., INC. (US) | 1993-03-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200277248-A1 | METHODS FOR THE REDUCTION OF CARBON DIOXIDE | CA5A, CA5B, FTO | NQO1 170/4885TSHR 3993/4885TDP1 3559/4885 |
| US-20210355064-A1 | METHODS RELATED TO CARBON DIOXIDE | CA1, CA5A, CA9 | NQO1 460/4885TSHR 4033/4885TDP1 3599/4885 |
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | BMP2, BMP4, BMP6 | NQO1 2074/4885TSHR 2887/4885TDP1 4775/4885 |
| US-11208379-B2 | Compounds, compositions, methods for treating diseases, and methods for preparing compounds | VHL, KRAS, C5 | NQO1 152/4885TSHR 4685/4885TDP1 2341/4885 |
| US-11078148-B2 | Methods for the reduction of carbon dioxide | CA5A, CA5B, FTO | NQO1 170/4885TSHR 3993/4885TDP1 3559/4885 |
| US-20080223444-A1 | Perylene Charge-Transport Materials, Methods of Fabrication Thereof, and Methods of Use Thereof | SLC43A1, SLC3A2, SLC16A3 | NQO1 1178/4885TSHR 4842/4885TDP1 924/4885 |
| US-20060045846-A1 | Reagents and methods for labeling terminal olefins | EEF2, RNF168, REL | NQO1 1800/4885TSHR 469/4885TDP1 3131/4885 |
| US-20200079742-A1 | COMPOUNDS, COMPOSITIONS, METHODS FOR TREATING DISEASES, AND METHODS FOR PREPARING COMPOUNDS | VHL, C5, KRAS | NQO1 157/4885TSHR 4651/4885TDP1 2610/4885 |
| US-11312690-B2 | Compounds, compositions, methods for treating diseases, and methods for preparing compounds | VHL, C5, KRAS | NQO1 157/4885TSHR 4651/4885TDP1 2610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.