Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | USP19 | O94966 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107290 | 0.92 | CUL4A (0.43) | GCKUSP19MAPK8CUL4AALDH1A1 | |
| SCHEMBL9107847 | 0.88 | GCK (0.40) | GCKUSP19RENALDH1A1 | |
| SCHEMBL9103195 | 0.88 | DNMT1 (0.37) | GCKUSP19MAPK8CUL4AALDH1A1 | |
| SCHEMBL9108781 | 0.87 | F11 (0.38) | GCKRENMDM2 | |
| SCHEMBL9106688 | 0.87 | GCK (0.36) | GCKUSP19RENALDH1A1GAA | |
| SCHEMBL9107551 | 0.85 | RAB9A (0.36) | GCKUSP19RENALDH1A1GAA | |
| SCHEMBL9109747 | 0.84 | ALDH1A1 (0.46) | GCKUSP19RENALDH1A1GAA | |
| SCHEMBL9105979 | 0.82 | ALDH1A1 (0.44) | GCKALDH1A1 | |
| SCHEMBL9102207 | 0.81 | F11 (0.40) | GCKALDH1A1 | |
| SCHEMBL9105493 | 0.81 | PARK7 (0.39) | GCKALDH1A1GAANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | GPR119, INSR, OAT | GCK 488/4885USP19 3256/4885MAPK8 3592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.