Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215338 | 0.94 | MEN1 (0.41) | MEN1KMT2AADRA1AADRA1BHTR1A | |
| SCHEMBL9207731 | 0.84 | SIGMAR1 (0.43) | HTR1AHTR1BHTR1DDRD4HRH3 | |
| SCHEMBL9740252 | 0.79 | KMT2A (0.38) | MEN1KMT2AALDH1A1DRD4 | |
| SCHEMBL9739714 | 0.78 | MEN1 (0.38) | MEN1KMT2AHTR1ADRD4DRD1 | |
| SCHEMBL9739252 | 0.74 | KMT2A (0.42) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL9204729 | 0.74 | KDM2B (0.43) | HTR1AKDM4EALDH1A1SLC6A4ACHE | |
| SCHEMBL9738921 | 0.73 | HTR1A (0.48) | MEN1KMT2AHTR1AKDM4EALDH1A1 | |
| SCHEMBL9205099 | 0.72 | HRH3 (0.48) | KMT2AKDM4EALDH1A1DRD4HRH3 | |
| SCHEMBL9208504 | 0.72 | HRH2 (0.49) | KMT2AKDM4EALDH1A1HRH3HRH2 | |
| SCHEMBL9740195 | 0.71 | DRD2 (0.43) | HTR1ADRD4HRH1HTR7DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |