Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 7/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.40 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.40 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687454 | 0.83 | MEN1 (0.39) | EZH2MEN1KMT2AHTTKDM4E | |
| SCHEMBL9687392 | 0.83 | CYP1A2 (0.46) | MEN1KMT2ASMN1; SMN2HPGDHDAC1 | |
| SCHEMBL9689043 | 0.82 | HPGD (0.39) | MEN1KMT2AHTTNPC1SMN1; SMN2 | |
| SCHEMBL9688033 | 0.81 | HTT (0.49) | MEN1KMT2AHTTNPC1SMN1; SMN2 | |
| SCHEMBL9688037 | 0.79 | TSHR (0.49) | KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL9280239 | 0.79 | RXFP1 (0.45) | MEN1KMT2AHTTNPC1SMN1; SMN2 | |
| SCHEMBL9687391 | 0.78 | HPGD (0.39) | MEN1KMT2AHTTNPC1SMN1; SMN2 | |
| SCHEMBL9278822 | 0.75 | RAB9A (0.46) | MEN1KMT2AHTTNPC1SMN1; SMN2 | |
| SCHEMBL9687611 | 0.73 | KMT2A (0.48) | MEN1KMT2AHTTNPC1SMN1; SMN2 | |
| SCHEMBL9164617 | 0.71 | NPC1 (0.51) | MEN1KMT2ANPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |