SCHEMBL93033

SCHEMBL93033

CCCCOc1c(C=O)occc1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.40
LMNA P02545 2/20 0.40
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ALDH1A1 P00352 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
KMT2A Q03164 2/20 0.38
SIGMAR1 Q99720 3/20 0.36
LDHA P00338 3/20 0.36
MEN1 O00255 1/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP19A1 P11511 1/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7605190 0.80 ADORA3 (0.47) GAALMNAALDH1A1KDM4EMAPT
SCHEMBL92986 0.80 LMNA (0.59) GAALMNAALDH1A1NPSR1KDM4E
SCHEMBL11465930 0.79 ALDH2 (0.40) TDP1ALDH1A1KDM4ETSHR
SCHEMBL19330052 0.76 ADORA3 (0.42) GAALMNAALDH1A1KDM4EMAPT
SCHEMBL13413902 0.75 ALDH1A1 (0.44) LMNAALDH1A1NPSR1KDM4EMAPT
SCHEMBL28507838 0.74 LMNA (0.64) GAALMNAL3MBTL1ALDH1A1NPSR1
SCHEMBL86297 0.74 LMNA (0.64) GAALMNAL3MBTL1ALDH1A1NPSR1
SCHEMBL93031 0.74 LMNA (0.42) GAALMNATDP1L3MBTL1KMT2A
SCHEMBL19346550 0.73 LMNA (0.33) GAALMNAKDM4EKMT2A
SCHEMBL13946439 0.73 KMT2A (0.38) GAALMNAKDM4EMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2370419-B1 MALTOL ETHER PROCESSES AND INTERMEDIATES SHIONOGI & CO (JP) 2017-09-27 EP disclosed
US-20170267693-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2017-09-21 US disclosed
US-20170260203-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2017-09-14 US disclosed
WO-2017153919-A1 TRICYCLIC COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS NOVARTIS AG (CH) 2017-09-14 WO disclosed
EP-2376080-B1 SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES SHIONOGI & CO (JP) 2017-09-13 EP disclosed
US-20170253616-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2017-09-07 US disclosed
EP-3210603-A1 SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES SHIONOGI & CO., LTD (JP) 2017-08-30 EP disclosed
US-20170224695-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2017-08-10 US disclosed
US-20170224694-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2017-08-10 US disclosed
US-20170209454-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2017-07-27 US disclosed
US-20120115875-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY GLAXOSMITHKLINE LLC 2012-05-10 US disclosed
US-8129385-B2 Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness SHIONOGI & CO., LTD. (JP) 2012-03-06 US disclosed
US-20110263855-A1 PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS SHIONOGI & CO., LTD. (JP) 2011-10-27 US disclosed
US-20110245516-A1 MALTOL ETHER PROCESSES AND INTERMEDIATES SHIONOGI & CO., LTD. (JP) 2011-10-06 US disclosed
WO-2010068262-A1 PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2010-06-17 WO disclosed
WO-2010067176-A1 MALTOL ETHER PROCESSES AND INTERMEDIATES SHIONOGI & CO., LTD. (JP) 2010-06-17 WO disclosed
WO-2010068253-A1 SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES SHIONOGI & CO., LTD. (JP) 2010-06-17 WO disclosed
US-20100098640-A1 Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE 2010-04-22 US disclosed
US-20090318421-A1 Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity VIIV HEALTHCARE COMPANY 2009-12-24 US disclosed
WO-2007002109-A2 MULTIDENTATE PYRONE-DERIVED CHELATORS FOR MEDICINAL IMAGING AND CHELATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170209454-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY NR4A1, NCOA4, NR4A2 GAA 3623/4885LMNA 4751/4885TDP1 2213/4885
US-20120115875-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY NR4A1, NCOA4, NR4A2 GAA 3615/4885LMNA 4751/4885TDP1 2208/4885
US-20170260203-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY NR4A1, NCOA4, NR4A2 GAA 3623/4885LMNA 4751/4885TDP1 2213/4885
US-20110263855-A1 PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS INTS6, IDH1, OPRM1 GAA 3087/4885LMNA 3139/4885TDP1 2645/4885
US-20170224694-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY NR4A1, NCOA4, NR4A2 GAA 3623/4885LMNA 4751/4885TDP1 2213/4885
US-20110245516-A1 MALTOL ETHER PROCESSES AND INTERMEDIATES CYP3A4, CYP2E1, MALT1 GAA 314/4885LMNA 4109/4885TDP1 3047/4885
US-20170253616-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY NR4A1, NCOA4, NR4A2 GAA 3695/4885LMNA 4737/4885TDP1 2192/4885
US-20170224695-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY NCOA4, NR4A1, NR4A2 GAA 3600/4885LMNA 4744/4885TDP1 2210/4885
US-20090318421-A1 Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity NR4A1, NCOA4, NR4A2 GAA 3615/4885LMNA 4751/4885TDP1 2208/4885
US-20100098640-A1 Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation DNM1, BET1, FOLH1 GAA 594/4885LMNA 2576/4885TDP1 1326/4885
US-20170267693-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY NR4A1, NCOA4, NR4A2 GAA 3623/4885LMNA 4751/4885TDP1 2213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.