Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302144 | 0.92 | GRM5 (0.39) | GRM5CPT1AOPRM1OPRD1OPRK1 | |
| SCHEMBL9302252 | 0.91 | ACHE (0.42) | GRM5OPRM1OPRD1OGFRL1LMNA | |
| SCHEMBL9301733 | 0.82 | CYP11B2 (0.40) | CPT1AALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL9303690 | 0.81 | OPRM1 (0.37) | CPT1AOPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL9303370 | 0.78 | ALDH1A1 (0.43) | GRM5ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9847718 | 0.77 | CYP11B2 (0.35) | CPT1AOPRM1OPRD1OGFRL1ALDH1A1 | |
| SCHEMBL9301682 | 0.76 | RORC (0.42) | OPRM1OPRD1OGFRL1SMN1; SMN2LMNA | |
| SCHEMBL9303809 | 0.76 | HTT (0.41) | OPRM1OPRD1OGFRL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9301471 | 0.74 | RORC (0.41) | OPRM1OPRD1OGFRL1SMN1; SMN2LMNA | |
| SCHEMBL9847732 | 0.73 | HTT (0.43) | OPRM1OPRD1OGFRL1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283248-A | Bactericides, enzyme inhibitor of DNA-gyrase in bacteria | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |