Acrylamide

Acrylamide

SCHEMBL9325809

C=CC(N)=O.O=S(=O)([O-])C=Cc1ccccc1.[Na+]

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG known ✓ P37231 3/20 0.40
HTT P42858 2/20 0.41
LMNA P02545 3/20 0.40
KMT2A Q03164 2/20 0.40
NFE2L2 Q16236 1/20 0.40
GAA P10253 2/20 0.39
CYP2C19 P33261 1/20 0.39
ALDH1A1 P00352 2/20 0.39
HDAC3 O15379 1/20 0.39
TNKS O95271 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HCAR2 Q8TDS4 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylamide SCHEMBL3052974 0.97 HTT (0.41) HTTLMNAPPARGKMT2ANFE2L2
Acrylic Acid SCHEMBL28294518 0.90 HDAC3 (0.46) HTTLMNAPPARGKMT2ANFE2L2
Acrylic Acid SCHEMBL6279451 0.89 HTT (0.42) HTTLMNAPPARGKMT2ANFE2L2
Acrylic Acid SCHEMBL16564294 0.87 HDAC3 (0.46) HTTLMNAPPARGKMT2ANFE2L2
Acrylamide SCHEMBL8742738 0.87 HTT (0.43) HTTLMNAPPARGKMT2ANFE2L2
SCHEMBL28223837 0.86 PPARG (0.44) HTTLMNAPPARGKMT2ANFE2L2
Vinylsulfonic Acid SCHEMBL29204743 0.84 PPARG (0.46) HTTLMNAPPARGKMT2ANFE2L2
Butadiene SCHEMBL28640925 0.84 PPARG (0.46) HTTLMNAPPARGKMT2ANFE2L2
Butadiene SCHEMBL10352729 0.84 PPARG (0.46) HTTLMNAPPARGKMT2ANFE2L2
SCHEMBL4339905 0.84 PPARG (0.52) HTTLMNAPPARGKMT2ANFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5371560-A For overhead projectors MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-12-06 US disclosed
US-5237355-A Envelope for transparency having increased flexibility MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-08-17 US disclosed
US-4584339-A TWO WATER SOLUBLE COPOLYMERS, ONE CONTAINING CATIONIC COMONOMERS, THE OTHER CONTAINING ANIONIC COMONOMERS EXXON RESEARCH AND ENGINEERING CO. (US) 1986-04-22 US disclosed
US-4536539-A Dilatant behavior of interpolymer complexes in aqueous solution EXXON RESEARCH AND ENGINEERING CO. (US) 1985-08-20 US disclosed
US-4517333-A BLEND OF ANIONIC AND CATIONIC POLYMERS, LUBRICANTS EXXON RESEARCH AND ENGINEERING CO. (US) 1985-05-14 US disclosed
US-4489180-A ANIONIC AND CATIONIC COPOLYMERS EXXON RESEARCH AND ENGINEERING CO. (US) 1984-12-18 US disclosed