Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.40 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL28294518 | 0.92 | HDAC3 (0.46) | HTTTDP1GLALMNAPPARG | |
| Acrylic Acid SCHEMBL8759859 | 0.90 | HTT (0.42) | HTTTDP1GLALMNAPPARG | |
| Acrylamide SCHEMBL9325809 | 0.89 | HTT (0.41) | HTTTDP1GLALMNAPPARG | |
| Acrylic Acid SCHEMBL16564294 | 0.88 | HDAC3 (0.46) | HTTTDP1GLALMNAPPARG | |
| Fumaric Acid SCHEMBL4345633 | 0.88 | LMNA (0.46) | HTTTDP1GLALMNAPPARG | |
| Fumaric Acid SCHEMBL4345636 | 0.88 | LMNA (0.46) | HTTTDP1GLALMNAPPARG | |
| Fumaric Acid SCHEMBL4346408 | 0.88 | LMNA (0.46) | HTTTDP1GLALMNAPPARG | |
| SCHEMBL28223837 | 0.88 | PPARG (0.44) | HTTLMNAPPARGNFE2L2KMT2A | |
| Acrylic Acid SCHEMBL28738269 | 0.87 | HTT (0.40) | HTTTDP1GLALMNAPPARG | |
| Acrylic Acid SCHEMBL16564293 | 0.87 | HTT (0.42) | HTTTDP1GLALMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9983327-B2 | Polymer coated nanoparticles | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-05-29 | — | — | US | disclosed |
| US-20150268370-A1 | POLYMER COATED NANOPARTICLES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-09-24 | — | — | US | disclosed |
| WO-2014066793-A1 | POLYMER COATED NANOPARTICLES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-05-01 | — | — | WO | disclosed |
| EP-1291334-B1 | Anti-bonding agents and methods for blast furnace slag or its grading adjusted slag | TAKEMOTO OIL & FAT CO LTD (JP) | 2013-10-23 | — | — | EP | disclosed |
| CN-1239528-C | Anti-coagulation agent and anti-coagulation method for blast furnace water granulated slag or particle size adjustment thereof | STEEL PIPE & MINING INDUSTRY C (JP) | 2006-02-01 | — | — | CN | disclosed |
| US-6936673-B2 | Anti-bonding methods for blast furnace slag or its grading adjusted slag | TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) | 2005-08-30 | — | — | US | disclosed |
| US-20050065306-A1 | Anti-bonding methods for blast furnace slag or its grading adjusted slag | KOKAN MINING CO., LTD., A CORPORATION OF JAPAN | 2005-03-24 | — | — | US | disclosed |
| US-20030110896-A1 | Anti-bonding agents and methods for blast furnace slag or its grading adjusted slag | KOKAN MINING CO., LTD. | 2003-06-19 | — | — | US | disclosed |
| CN-1407118-A | Anti-coagulation agent and anti-coagulation method for blast furnace water granulated slag or particle size adjustment thereof | STEEL PIPE & MINING INDUSTRY C (JP) | 2003-04-02 | — | — | CN | disclosed |
| EP-1291334-A2 | Anti-bonding agents and methods for blast furnace slag or its grading adjusted slag | Takemoto Yushi Kabushiki Kaisha (JP) | 2003-03-12 | — | — | EP | disclosed |