Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11453750 | 0.81 | CYP2D6 (0.34) | KEAP1NFE2L2ALDH1A1KDM4EMEN1 | |
| SCHEMBL27555136 | 0.76 | CYP2D6 (0.33) | KEAP1NFE2L2ALDH1A1KDM4ECYP2D6 | |
| SCHEMBL20168656 | 0.74 | KEAP1 (0.37) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR | |
| SCHEMBL9129355 | 0.74 | ALDH1A1 (0.35) | KEAP1NFE2L2ALDH1A1KDM4EMEN1 | |
| SCHEMBL27957330 | 0.74 | KEAP1 (0.37) | KEAP1NFE2L2ALDH1A1KDM4ENPC1 | |
| SCHEMBL19690668 | 0.74 | NAAA (0.35) | EPHX2 | |
| SCHEMBL27334904 | 0.73 | FFAR3 (0.31) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5239699 | 0.73 | ADRA1A (0.37) | KDM4ESMN1; SMN2HIF1AEPHX2 | |
| SCHEMBL25429424 | 0.72 | KEAP1 (0.36) | KEAP1NFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL10358243 | 0.72 | KEAP1 (0.36) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307434-B2 | Nucleic acid prodrugs and methods of use thereof | WAVE LIFE SCIENCES LTD. (SG) | 2019-06-04 | — | — | US | disclosed |
| US-9744183-B2 | Nucleic acid prodrugs and methods of use thereof | WAVE LIFE SCIENCES LTD. (SG) | 2017-08-29 | — | — | US | disclosed |
| US-20160347784-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES PTE. LTD. (SG) | 2016-12-01 | — | — | US | disclosed |
| US-20120316224-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF | ONTORII, INC (US) | 2012-12-13 | — | — | US | disclosed |
| EP-2451461-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF | Ontorii, Inc (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005761-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS USE THEREOF | ONTORII, INC (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316224-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF | PNP, RNGTT, TYMP | KEAP1 4528/4885NFE2L2 4637/4885ALDH1A1 1085/4885 |
| US-20160347784-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF | PNP, RNGTT, TYMP | KEAP1 4528/4885NFE2L2 4637/4885ALDH1A1 1085/4885 |
| US-10307434-B2 | Nucleic acid prodrugs and methods of use thereof | PNP, RNGTT, NSUN2 | KEAP1 4483/4885NFE2L2 4436/4885ALDH1A1 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.