Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29896649 | 1.00 | IDO1 (0.39) | IDO1TDO2HTTALDH1A1CYP2C19 | |
| SCHEMBL28343103 | 0.85 | ALDH1A1 (0.36) | IDO1TDO2HTTALDH1A1CYP2C19 | |
| SCHEMBL22824151 | 0.82 | HTT (0.40) | IDO1TDO2HTTALDH1A1CYP2C19 | |
| SCHEMBL898540 | 0.77 | ESR1 (0.50) | ALDH1A1CYP2C19CYP3A4L3MBTL1CYP2C9 | |
| SCHEMBL699772 | 0.77 | ALDH1A1 (0.38) | ALDH1A1CYP2C19CYP3A4ALOX15L3MBTL1 | |
| SCHEMBL29898831 | 0.76 | KAT6A (0.32) | CYP3A4ALOX15HPGDTSHR | |
| SCHEMBL933830 | 0.76 | KAT6A (0.32) | CYP3A4ALOX15HPGDTSHR | |
| SCHEMBL6325 | 0.76 | CYP2C19 (0.44) | IDO1TDO2HTTALDH1A1CYP2C19 | |
| SCHEMBL29369499 | 0.76 | CYP2C19 (0.44) | IDO1TDO2HTTALDH1A1CYP2C19 | |
| SCHEMBL5397237 | 0.75 | CA1 (0.48) | IDO1TDO2HTTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240190854-A1 | PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS | KING'S COLLEGE LONDON (GB) | 2024-06-13 | — | — | US | disclosed |
| US-20240174663-A1 | PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS | KING'S COLLEGE LONDON (GB) | 2024-05-30 | — | — | US | disclosed |
| US-11918984-B2 | Annulation catalysts via direct C—H bond amination | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2024-03-05 | — | — | US | disclosed |
| US-11912786-B2 | Inhibitor of apoptosis protein (IAP) antagonists | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-27 | — | — | US | disclosed |
| EP-4301751-A1 | PYRIMIDINE OR PYRIDINE DERIVATES USEFUL AS HCN2 MODULATORS | King's College London (GB) | 2024-01-10 | — | — | EP | disclosed |
| EP-4301745-A1 | PYRIMIDINE OR PYRIDINE DERIVATES USEFUL AS HCN2 MODULATORS | King's College London (GB) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022185055-A1 | PYRIMIDINE OR PYRIDINE DERIVATES USEFUL AS HCN2 MODULATORS | KING'S COLLEGE LONDON (GB) | 2022-09-09 | — | — | WO | disclosed |
| US-11324827-B2 | Multifunctionalized polyethylene glycol derivative and preparation method therefor | XIAMEN SINOPEG BIOTECH CO., LTD. (CN) | 2022-05-10 | — | — | US | disclosed |
| US-20220016613-A1 | NOVEL ANNULATION CATALYSTS VIA DIRECT C-H BOND AMINATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-01-20 | — | — | US | disclosed |
| CN-211384996-U | Formamido phenyl boric acid preparation reaction kettle device | 武汉利昌医药科技有限公司 | 2020-09-01 | — | — | CN | disclosed |
| CN-1017893-B | PROCESS FOR THE PREPARATION OF HETEROCYCLIC DERIVATIVES | GLAXO SPA (IT) | 1992-08-19 | — | — | CN | disclosed |
| US-5011848-A | Cardiovascular disorders, hypotensive agents | GLAXO, S.P.A. (IT) | 1991-04-30 | — | — | US | disclosed |
| US-4801599-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | GLAXO S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |
| CN-85107087-A | The preparation technology of Hete rocyclic derivatives | — | 1986-12-31 | — | — | CN | disclosed |
| US-4421924-A | FROM GULONO-1,4-LACTONE | PFIZER INC. (US) | 1983-12-20 | — | — | US | disclosed |
| US-4283340-A | VITAMINS | PFIZER INC. (US) | 1981-08-11 | — | — | US | disclosed |
| EP-0000243-B1 | PROCESS FOR PREPARING 3,5:4,6- PROTECTED DERIVATIVES OF L- OR D- GULONIC ACID, THEIR USE IN PREPARING 2- KETO-L- OR D- GULONIC ACID OR THEIR ESTERS OR L- OR D- ASCORBIC ACID, AND CERTAIN NOVEL 2-NITRATO-GULONATE INTERMEDIATES | PFIZER INC. (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4232168-A | OXIDATION, HYDROLYSIS | PFIZER INC. (US) | 1980-11-04 | — | — | US | disclosed |
| EP-0000243-A1 | Process for preparing 3,5:4,6- protected derivatives of L- or D- gulonic acid, their use in preparing 2- keto-L- or D- gulonic acid or their esters or L- or D- ascorbic acid, and certain novel 2-nitrato-gulonate intermediates | PFIZER INC. (US) | 1979-01-10 | — | — | EP | disclosed |
| US-4038386-A | INOTROPIC AGENTS | DEUTSCH GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) | 1977-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240190854-A1 | PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS | HCN2, HCN1, HCN3 | IDO1 2567/4885TDO2 2594/4885HTT 434/4885 |
| US-11918984-B2 | Annulation catalysts via direct C—H bond amination | AADAC, AOC1, CAD | IDO1 915/4885TDO2 2322/4885HTT 1904/4885 |
| US-20220016613-A1 | NOVEL ANNULATION CATALYSTS VIA DIRECT C-H BOND AMINATION | AADAC, CAD, AOC1 | IDO1 618/4885TDO2 1875/4885HTT 1986/4885 |
| US-20240174663-A1 | PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS | HCN2, HCN1, HCN3 | IDO1 2581/4885TDO2 2279/4885HTT 375/4885 |
| US-11912786-B2 | Inhibitor of apoptosis protein (IAP) antagonists | API5, XIAP, BIRC5 | IDO1 2419/4885TDO2 4660/4885HTT 2134/4885 |
| US-11324827-B2 | Multifunctionalized polyethylene glycol derivative and preparation method therefor | HDGF, F11, F12 | IDO1 4313/4885TDO2 4218/4885HTT 3622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.