Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3530679 | 0.92 | KEAP1 (0.50) | KEAP1KDM4EKMT2ATDP1MEN1 | |
| SCHEMBL19131130 | 0.84 | GABRP (0.47) | KEAP1KDM4EKMT2ATDP1MEN1 | |
| SCHEMBL30079667 | 0.83 | KDM4E (0.52) | KEAP1KDM4EKMT2ATDP1MEN1 | |
| SCHEMBL222733 | 0.83 | KEAP1 (0.57) | KEAP1KDM4EKMT2ATDP1MEN1 | |
| SCHEMBL3436916 | 0.83 | KDM4E (0.45) | KEAP1KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL974647 | 0.83 | KDM4E (0.52) | KEAP1KDM4EKMT2ATDP1MEN1 | |
| SCHEMBL19399612 | 0.81 | KEAP1 (0.44) | KEAP1KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL365017 | 0.81 | KDM4E (0.44) | KEAP1KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL28347494 | 0.81 | KDM4E (0.50) | KEAP1KDM4EKMT2ATDP1MEN1 | |
| Hydrochloric Acid SCHEMBL9388380 | 0.81 | KMT2A (0.52) | KEAP1KDM4EKMT2ATDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12473291-B2 | Benzodiazepine compound, preparation method therefor, and use thereof in medicine | WEST CHINA HOSPITAL, SICHUAN UNIVERSITY (CN) | 2025-11-18 | — | — | US | disclosed |
| US-11919905-B2 | Substituted benzo[f]imidazo[1,2-a][1,4]diazepines as anesthetics | Hangzhou Adamerck Pharmlabs, Inc. (CN) | 2024-03-05 | — | — | US | disclosed |
| EP-3730495-B1 | PYRIDYL IMIDAZOBENZODIAZEPINE PROPIONATE COMPOUND AND SYNTHESIS AND USE THEREOF | HANGZHOU ADAMERCK PHARMLABS INC (CN) | 2024-02-07 | — | — | EP | disclosed |
| CN-111727190-B | Pyridylimidazole benzodiazepine Zhuo Bingsuan ester compound and synthesis and application thereof | 杭州奥默医药股份有限公司 | 2023-10-27 | — | — | CN | disclosed |
| US-20220372037-A1 | PYRIDYL IMIDAZOBENZODIAZEPINE PROPIONATE COMPOUND AND SYNTHESIS AND USE THEREOF | Hangzhou Adamerck Pharmlabs Inc. (CN) | 2022-11-24 | — | — | US | disclosed |
| US-20220324867-A1 | BENZODIAZEPINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | WEST CHINA HOSPITAL, SICHUAN UNIVERSITY (CN) | 2022-10-13 | — | — | US | disclosed |
| EP-3992194-A1 | BENZODIAZEPINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | West China Hospital, Sichuan University (CN) | 2022-05-04 | — | — | EP | disclosed |
| CN-112142746-B | Benzodiazepine compound, preparation method and medical application thereof | 四川大学华西医院 | 2021-09-24 | — | — | CN | disclosed |
| CN-108033964-B | Pyridyl imidazobenzodiazepine propionate compound and synthesis and application thereof | 杭州奥默医药股份有限公司 | 2021-02-09 | — | — | CN | disclosed |
| CN-112142746-A | Benzodiazepine compound, preparation method and medical application thereof | 四川大学华西医院 | 2020-12-29 | — | — | CN | disclosed |
| EP-1608632-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | disclosed |
| EP-1608632-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | disclosed |
| US-20060217377-A1 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2006-09-28 | — | — | US | disclosed |
| CN-1784391-A | Quinazolines useful as modulators of ion channels | VERTEX PHARMA (US) | 2006-06-07 | — | — | CN | disclosed |
| EP-1608632-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20040248890-A1 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2004-12-09 | — | — | US | disclosed |
| WO-2004078733-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-16 | — | — | WO | disclosed |
| WO-2004078733-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-16 | — | — | WO | disclosed |
| US-4762844-A | ANIMAL GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-09 | — | — | US | disclosed |
| EP-0181588-A2 | Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, process for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11919905-B2 | Substituted benzo[f]imidazo[1,2-a][1,4]diazepines as anesthetics | GABRA1, GABRA4, GABRA6 | KEAP1 4266/4885KDM4E 378/4885KMT2A 440/4885 |
| US-20220324867-A1 | BENZODIAZEPINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | GABRA1, GABRA4, GABRR1 | KEAP1 1767/4885KDM4E 833/4885KMT2A 653/4885 |
| US-20220372037-A1 | PYRIDYL IMIDAZOBENZODIAZEPINE PROPIONATE COMPOUND AND SYNTHESIS AND USE THEREOF | GABBR1, GABRA1, GABRA6 | KEAP1 4211/4885KDM4E 261/4885KMT2A 446/4885 |
| US-20040248890-A1 | Quinazolines useful as modulators of ion channels | KCNN3, KCNN2, CACNA1I | KEAP1 690/4885KDM4E 2502/4885KMT2A 2608/4885 |
| US-20060217377-A1 | Quinazolines useful as modulators of ion channels | KCNN3, KCNN2, CACNA1I | KEAP1 690/4885KDM4E 2502/4885KMT2A 2608/4885 |
| US-12473291-B2 | Benzodiazepine compound, preparation method therefor, and use thereof in medicine | GABRA1, GABRA4, GABRR1 | KEAP1 1767/4885KDM4E 833/4885KMT2A 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.