Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.49 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.46 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513919 | 1.00 | HSPD1 (0.63) | HSPD1BLMHSPE1CA2MEN1 | |
| SCHEMBL9724548 | 1.00 | HSPD1 (0.63) | HSPD1BLMHSPE1CA2MEN1 | |
| Glycerin SCHEMBL9754370 | 0.92 | HSPD1 (0.58) | HSPD1BLMHSPE1CA2MEN1 | |
| SCHEMBL31158245 | 0.91 | HSPD1 (0.51) | HSPD1BLMHSPE1CA2MEN1 | |
| SCHEMBL9492990 | 0.88 | HSPD1 (0.51) | HSPD1BLMHSPE1CA2MEN1 | |
| Zinc Ion SCHEMBL9496396 | 0.88 | HSPD1 (0.51) | HSPD1BLMHSPE1CA2MEN1 | |
| Potassium Ion SCHEMBL31158247 | 0.88 | HSPD1 (0.51) | HSPD1BLMHSPE1CA2MEN1 | |
| Tetramethylammonium Ion SCHEMBL31158235 | 0.85 | HSPD1 (0.49) | HSPD1BLMHSPE1CA2MEN1 | |
| SCHEMBL9724550 | 0.83 | HSPD1 (0.66) | HSPD1BLMHSPE1CA2MEN1 | |
| SCHEMBL9513929 | 0.83 | HSPD1 (0.66) | HSPD1BLMHSPE1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282289-B1 | Cosmetic composition | UNILEVER PLC (GB) | 1993-12-22 | — | — | EP | disclosed |
| US-5089531-A | Compositions incorporating a salt of monoester of citric acid and a method for synthesizing the monoester | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282289-A1 | Cosmetic composition | UNILEVER PLC (GB) | 1988-09-14 | — | — | EP | disclosed |