SCHEMBL954459

SCHEMBL954459

O=C(O)Cc1cccc(OCc2ccccc2)c1

nearest known ligand 0.70

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.66
FFAR1 O14842 1/20 0.64
CYP4F2 P78329 1/20 0.63
CYP4A11 Q02928 1/20 0.63
MAOB P27338 5/20 0.62
LTB4R Q15722 1/20 0.62
LTB4R2 Q9NPC1 1/20 0.62
SMN1; SMN2 Q16637 2/20 0.59
TSHR P16473 1/20 0.59
SMPD1 P17405 1/20 0.59
KMT2A Q03164 1/20 0.58
BCHE P06276 1/20 0.58
NAAA Q02083 1/20 0.58
KDM4E B2RXH2 1/20 0.57
ALDH1A1 P00352 1/20 0.57
PKM P14618 1/20 0.57
SRD5A2 P31213 1/20 0.57
MAOA P21397 1/20 0.57
PTPN1 P18031 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3511533 0.94 FFAR1 (0.59) NR4A2FFAR1CYP4F2CYP4A11MAOB
SCHEMBL3908596 0.91 CFD (0.66) NR4A2FFAR1MAOBLTB4RLTB4R2
SCHEMBL15297882 0.89 MAOB (0.63) NR4A2FFAR1CYP4F2CYP4A11MAOB
SCHEMBL5090803 0.89 NR4A2 (0.68) NR4A2FFAR1MAOBLTB4RLTB4R2
SCHEMBL14514248 0.89 FFAR1 (0.57) NR4A2FFAR1CYP4F2CYP4A11MAOB
SCHEMBL14032965 0.89 LCK (0.66) NR4A2FFAR1CYP4F2CYP4A11MAOB
SCHEMBL9080535 0.88 MRGPRX4 (0.60) NR4A2FFAR1MAOBLTB4RLTB4R2
SCHEMBL9205498 0.88 LTB4R (0.68) NR4A2FFAR1CYP4F2CYP4A11MAOB
SCHEMBL2957881 0.88 MEN1 (0.67) NR4A2FFAR1CYP4F2CYP4A11MAOB
SCHEMBL5017852 0.87 PLA2G4B (0.56) NR4A2FFAR1CYP4F2CYP4A11MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 225 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3517109-A1 COMPOUNDS AND METHOD FOR REDUCING URIC ACID Wellstat Therapeutics Corporation (US) 2019-07-31 EP claimed
US-9115072-B2 Compounds and method for reducing uric acid WELLSTAT THERAPEUTICS CORPORATION (US) 2015-08-25 US claimed
CN-101969773-B compounds and methods for reducing uric acid WELLSTAT THERAPEUTICS CORP. (US) 2015-08-19 CN claimed
US-20130259850-A1 COMPOUNDS AND METHOD FOR REDUCING URIC ACID WELLSTAT THERAPEUTICS CORPORATION (US) 2013-10-03 US claimed
CN-101969773-A compounds and methods for reducing uric acid WELLSTAT THERAPEUTICS CORP 2011-02-09 CN claimed
US-20110014176-A1 COMPOUNDS AND METHOD FOR REDUCING URIC ACID WELLSTAT THERAPEUTICS CORPORATION (US) 2011-01-20 US claimed
EP-2268141-A1 COMPOUNDS AND METHOD FOR REDUCING URIC ACID Wellstat Therapeutics Corporation (US) 2011-01-05 EP claimed
WO-2009151695-A1 COMPOUNDS AND METHOD FOR REDUCING URIC ACID WELLSTAT THERAPEUTICS CORPORATION (US) 2009-12-17 WO claimed
JP-51133246-A None JP disclosed
US-12552770-B2 Compounds for treating respiratory disease TMEM16A LIMITED (GB) 2026-02-17 US disclosed
US-20250320195-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS INC (US) 2025-10-16 US disclosed
EP-4559918-A2 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Genzyme Corporation (US) 2025-05-28 EP disclosed
EP-3673906-B1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORP (US) 2025-05-14 EP disclosed
US-12172981-B2 Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders ARVINAS OPERATIONS, INC. (US) 2024-12-24 US disclosed
EP-0249245-A2 Antihypertensive dihydropyridine derivatives LABORATOIRES SYNTEX S.A. (FR) 1987-12-16 EP disclosed
EP-0112669-B1 PHENETHYLAMINE DERIVATIVES AND INTERMEDIATES THEREFOR AMERICAN HOME PRODUCTS CORPORATION (US) 1987-07-29 EP disclosed
US-4611078-A ANTIDEPRESSANT INTERMEDIATES AMERICAN HOME PRODUCTS CORPORATION (US) 1986-09-09 US disclosed
US-4535186-A CENTRAL NERVOUS SYSTEM ANTIDEPRESSANTS; VENLAFAXINE AMERICAN HOME PRODUCTS CORPORATION (US) 1985-08-13 US disclosed
EP-0112669-A2 Phenethylamine derivatives and intermediates therefor AMERICAN HOME PRODUCTS CORPORATION (US) 1984-07-04 EP disclosed
JP-S51133246-A PROCESS FOR PREPARING 3- BENZYLOXYPHENYLACETIC ACIDS GRELAN PHARMACEUT CO LTD 1976-11-18 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12552770-B2 Compounds for treating respiratory disease TMEM109, SCN1A, SLC16A1 NR4A2 910/4885FFAR1 710/4885CYP4F2 2990/4885
US-12172981-B2 Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders MDM2, CRBN, VHL NR4A2 159/4885FFAR1 3895/4885CYP4F2 2577/4885
US-20130259850-A1 COMPOUNDS AND METHOD FOR REDUCING URIC ACID RCC2, HAX1, SLC10A6 NR4A2 1494/4885FFAR1 5/4885CYP4F2 392/4885
US-20250320195-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS MDM2, CRBN, VHL NR4A2 159/4885FFAR1 3895/4885CYP4F2 2577/4885
US-20110014176-A1 COMPOUNDS AND METHOD FOR REDUCING URIC ACID UGP2, TAS2R46, PYCARD NR4A2 1952/4885FFAR1 513/4885CYP4F2 2060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.