Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSE | P14091 | 7/20 | 0.55 |
| ▸ | CTSD | P07339 | 6/20 | 0.55 |
| ▸ | PGC | P20142 | 1/20 | 0.55 |
| ▸ | REN | P00797 | 15/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PGA5 | P0DJD9 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556000 | 0.81 | REN (0.46) | CTSECTSDPGCRENALDH1A1 | |
| SCHEMBL7315594 | 0.79 | REN (0.45) | CTSECTSDPGCRENMEN1 | |
| SCHEMBL7322193 | 0.75 | REN (0.38) | CTSECTSDRENLMNASMN1; SMN2 | |
| SCHEMBL7329311 | 0.73 | ALDH1A1 (0.53) | CTSECTSDPGCRENMAPT | |
| SCHEMBL7320803 | 0.67 | REN (0.57) | CTSECTSDPGCRENPGA5 | |
| SCHEMBL7354500 | 0.60 | LMNA (0.60) | MAPTMEN1ALDH1A1LMNAHTT | |
| SCHEMBL7323392 | 0.60 | MEN1 (0.52) | RENMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4795306 | 0.59 | CTSS (0.53) | MEN1ALDH1A1LMNAKMT2AKDM4E | |
| SCHEMBL10373796 | 0.59 | ALDH1A1 (0.45) | MAPTMEN1ALDH1A1LMNAHTT | |
| SCHEMBL7319330 | 0.58 | ALDH1A1 (0.53) | MAPTMEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |