Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.45 |
| ▸ | CTSD | P07339 | 8/20 | 0.43 |
| ▸ | CTSE | P14091 | 7/20 | 0.43 |
| ▸ | PGA5 | P0DJD9 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PGC | P20142 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556000 | 0.85 | REN (0.46) | RENCTSDCTSEPGA5ALDH1A1 | |
| SCHEMBL9556283 | 0.79 | CTSE (0.55) | RENCTSDCTSEPGA5ALDH1A1 | |
| SCHEMBL7322193 | 0.75 | REN (0.38) | RENCTSDCTSEPGA5LMNA | |
| SCHEMBL4795306 | 0.64 | CTSS (0.53) | ALDH1A1GAALMNAKDM4EMEN1 | |
| SCHEMBL14516111 | 0.63 | ALDH1A1 (0.77) | ALDH1A1GAALMNAKDM4EMEN1 | |
| SCHEMBL7354500 | 0.62 | LMNA (0.60) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL13995385 | 0.62 | ALDH1A1 (1.00) | ALDH1A1GAALMNAKDM4EMEN1 | |
| SCHEMBL7319330 | 0.62 | ALDH1A1 (0.53) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL9556385 | 0.61 | ALDH1A1 (0.58) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL11146076 | 0.61 | LMNA (0.64) | ALDH1A1GAALMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0380805-A1 | Renin inhibitors containing C-terminal dihydroxy amides | WARNER-LAMBERT COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |
| WO-1990007521-A1 | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |