Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28414146 | 0.86 | MTNR1B (0.59) | MTNR1AMTNR1BKMT2AHDAC1MMP13 | |
| SCHEMBL9607439 | 0.84 | KMT2A (0.74) | KMT2AHDAC1LMNANPC1RAB9A | |
| SCHEMBL8993024 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BKMT2AHDAC1MMP13 | |
| SCHEMBL10069983 | 0.82 | NPC1 (0.60) | MTNR1AMTNR1BKMT2AHDAC1MMP13 | |
| SCHEMBL9607430 | 0.80 | SMN1; SMN2 (0.46) | MTNR1AMTNR1BKMT2AHDAC1LMNA | |
| SCHEMBL733307 | 0.79 | CES2 (0.67) | KMT2AHDAC1LMNAHPGDNPC1 | |
| SCHEMBL8093299 | 0.79 | MTNR1A (0.57) | MTNR1AMTNR1BKMT2ANPC1RAB9A | |
| SCHEMBL14191204 | 0.79 | LTA4H (0.70) | MTNR1AMTNR1BLMNA | |
| SCHEMBL9607483 | 0.79 | SMN1; SMN2 (0.66) | KMT2ALMNAHPGDNPC1RAB9A | |
| SCHEMBL2099512 | 0.79 | CHRM2 (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |