Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9622176 | 1.00 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MCHR1KMT2AMEN1 | |
| Fumaric Acid SCHEMBL9622178 | 1.00 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MCHR1KMT2AMEN1 | |
| SCHEMBL9367286 | 0.93 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2MCHR1KMT2AMEN1 | |
| SCHEMBL9367280 | 0.93 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2MCHR1KMT2AMEN1 | |
| SCHEMBL9622597 | 0.84 | LMNA (0.44) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL9622599 | 0.84 | LMNA (0.44) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL9622905 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2MCHR1KMT2ALMNA | |
| SCHEMBL9622908 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2MCHR1KMT2ALMNA | |
| SCHEMBL9622236 | 0.79 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2MCHR1KMT2ALMNA | |
| SCHEMBL9622231 | 0.79 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2MCHR1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126356-A | Antiischemic agents | ADIR ET COMPAGNIE (FR) | 1992-06-30 | — | — | US | disclosed |