Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.42 |
| ▸ | CYSLTR1 known ✓ | Q9Y271 | 1/20 | 0.37 |
| ▸ | ATP4A known ✓ | P20648 | 1/20 | 0.37 |
| ▸ | ATP4B known ✓ | P51164 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641845 | 0.90 | LMNA (0.44) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9518108 | 0.84 | ALOX5 (0.46) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9514403 | 0.80 | ALOX5 (0.47) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9642574 | 0.77 | MEN1 (0.52) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9642572 | 0.77 | MEN1 (0.52) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9518116 | 0.73 | ALOX5 (0.46) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9518105 | 0.73 | ALOX5 (0.46) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL10720978 | 0.71 | ALOX5 (0.48) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9514406 | 0.71 | ALOX5 (0.48) | ALOX5EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL9518052 | 0.70 | TOP2A (0.49) | ALOX5EPHX2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287471-B1 | CARBOXYSTYRENE DERIVATIVES AND DRUGS CONTAINING THEM AS EFFECTIVE INGREDIENTS | MITSUBISHI KASEI CORPORATION (JP) | 1992-09-09 | — | — | EP | disclosed |
| US-4925861-A | LEUKOTRIENE ANTAGONISTS, PHOSPHOLIPASE INHIBITORS | MITSUBISHI KASEI CORPORATION (JP) | 1990-05-15 | — | — | US | disclosed |
| EP-0287471-A2 | Carboxystyrene derivatives and drugs containing them as effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1988-10-19 | — | — | EP | disclosed |