Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688018 | 0.73 | MEN1 (0.49) | LMNASMN1; SMN2GAAHTTKMT2A | |
| SCHEMBL9164648 | 0.73 | KMT2A (0.47) | KMT2AMAPTTHRBALDH1A1RAB9A | |
| SCHEMBL9686788 | 0.72 | ALDH1A1 (0.43) | LMNASMN1; SMN2GAAHTTKMT2A | |
| SCHEMBL9687450 | 0.70 | HPGDS (0.48) | LMNASMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL9689051 | 0.68 | DCTPP1 (0.50) | LMNASMN1; SMN2KMT2AMAPTALDH1A1 | |
| SCHEMBL9686909 | 0.64 | KMT2A (0.46) | LMNAKMT2AMAPK1MAPTTHRB | |
| SCHEMBL7034123 | 0.61 | PDE3B (0.66) | LMNASMN1; SMN2GAAHTTPDE3B | |
| SCHEMBL16276101 | 0.61 | LMNA (0.64) | LMNASMN1; SMN2GAAHTTPDE3B | |
| SCHEMBL9403786 | 0.61 | PDE3B (0.58) | LMNASMN1; SMN2GAAHTTPDE3B | |
| SCHEMBL2821855 | 0.60 | KMT2A (0.65) | SMN1; SMN2HTTKMT2AMAPTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |