SCHEMBL969053

SCHEMBL969053

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)C(F)C1O

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 4/20 0.80
ADORA1 P30542 2/20 0.80
DPP4 P27487 1/20 0.80
MEN1 O00255 1/20 0.80
SLC28A1 O00337 1/20 0.80
MAP3K7 O43318 1/20 0.80
SLC28A2 O43868 1/20 0.80
GAPDH P04406 1/20 0.80
MAPK1 P28482 1/20 0.80
ADORA2A P29274 1/20 0.80
ADORA2B P29275 1/20 0.80
STAT6 P42226 1/20 0.80
PI4KA P42356 1/20 0.80
KMT2A Q03164 1/20 0.80
SMN1; SMN2 Q16637 1/20 0.80
PI4K2B Q8TCG2 1/20 0.80
DOT1L Q8TEK3 1/20 0.80
SLC29A1 Q99808 1/20 0.80
PI4K2A Q9BTU6 1/20 0.80
SLC28A3 Q9HAS3 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31160215 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL9737249 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL6721572 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL12150762 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL12300475 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL969049 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL12030590 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL6712774 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL21418729 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1
SCHEMBL30531775 1.00 ADORA3 (0.80) ADORA3ADORA1DPP4MEN1SLC28A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372725-B1 VIRICIDES, ANTICARCINOGENIC AND ANTITUMOR AGENTS; SIDE EFFECT REDUCTION HEIDELBERG PHARMA HOLDING GMBH (DE) 2002-04-16 US claimed
JP-1029394-A None JP disclosed
JP-3284691-A None JP disclosed
US-12370263-B2 Cyclic dinucleotide derivative based antibody-drug conjugates DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-07-29 US disclosed
US-20250188477-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-06-12 US disclosed
US-20250188478-A1 siRNA SUPPRESSING EXPRESSION OF TRANSFERRIN RECEPTOR 2 DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-06-12 US disclosed
WO-2025063239-A1 SIRNA CAPABLE OF SUPPRESSING EXPRESSION OF α-SYNUCLEIN 第一三共株式会社 2025-03-27 WO disclosed
WO-2025063238-A1 SIRNA FOR SUPPRESSING EXPRESSION OF PHOSPHOLAMBAN 第一三共株式会社 2025-03-27 WO disclosed
EP-4524154-A2 ANTIBODY-DRUG CONJUGATES OF CYCLIC DINUCLEOTIDE DERIVATIVES Daiichi Sankyo Company, Limited (JP) 2025-03-19 EP disclosed
EP-4504970-A1 COMPOSITIONS AND ANALYSIS OF DEPHOSPHORYLATED OLIGORIBONUCLEOTIDES New England Biolabs, Inc. (US) 2025-02-12 EP disclosed
US-20040110717-A1 Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase MERCK SHARP & DOHME LLC 2004-06-10 US disclosed
US-20040072788-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase BHAT BALKRISHEN (US) 2004-04-15 US disclosed
US-20040067901-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase MERCK SHARP & DOHME LLC 2004-04-08 US disclosed
US-20040014957-A1 Oligonucleotides having modified nucleoside units ISIS PHARMACEUTICALS, INC. 2004-01-22 US disclosed
US-20020147160-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase MERCK SHARP & DOHME LLC 2002-10-10 US disclosed
US-6372725-B1 VIRICIDES, ANTICARCINOGENIC AND ANTITUMOR AGENTS; SIDE EFFECT REDUCTION HEIDELBERG PHARMA HOLDING GMBH (DE) 2002-04-16 US disclosed
US-20020019363-A1 Method for the treatment or prevention of flavivirus infections using nucleoside analogues VIROCHEM PHARMA INC. (CA) 2002-02-14 US disclosed
US-5658890-A INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1997-08-19 US disclosed
JP-H03284691-A ANTIVIRAL NUCLEOSIDE ASAHI GLASS CO LTD 1991-12-16 JP disclosed
JP-S6429394-A PURINE NUCLEOSIDE DERIVATIVE ASAHI GLASS CO LTD 1989-01-31 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12370263-B2 Cyclic dinucleotide derivative based antibody-drug conjugates STING1, CGAS, CDA ADORA3 342/4885ADORA1 364/4885DPP4 1763/4885
US-20020019363-A1 Method for the treatment or prevention of flavivirus infections using nucleoside analogues NUDT1, HAVCR2, SLC28A1 ADORA3 1034/4885ADORA1 992/4885DPP4 358/4885
US-20040067901-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase NSUN2, NSUN3, POLRMT ADORA3 334/4885ADORA1 550/4885DPP4 749/4885
US-20040014957-A1 Oligonucleotides having modified nucleoside units RNASE1, RNASEH1, RNASEL ADORA3 464/4885ADORA1 539/4885DPP4 443/4885
US-20040110717-A1 Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase NSUN2, NSUN3, POLRMT ADORA3 304/4885ADORA1 493/4885DPP4 750/4885
US-20250188478-A1 siRNA SUPPRESSING EXPRESSION OF TRANSFERRIN RECEPTOR 2 TFRC, FOLR2, FTH1 ADORA3 3807/4885ADORA1 4046/4885DPP4 4471/4885
US-20040072788-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase NSUN2, NSUN3, POLRMT ADORA3 334/4885ADORA1 550/4885DPP4 749/4885
US-20020147160-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase NSUN2, NSUN3, POLRMT ADORA3 334/4885ADORA1 550/4885DPP4 749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.