Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727672 | 0.86 | ABCB1 (0.43) | DRD2 | |
| SCHEMBL9727737 | 0.83 | ESR1 (0.42) | MEN1KMT2AADRB2ESR1CYP19A1 | |
| SCHEMBL9727495 | 0.75 | ALDH1A1 (0.43) | MEN1KMT2AESR1ESR2 | |
| SCHEMBL9727705 | 0.71 | ABCB1 (0.41) | DRD2MEN1KMT2A | |
| SCHEMBL9727477 | 0.67 | MTNR1B (0.37) | DRD2DRD4DRD3ESR1CYP19A1 | |
| SCHEMBL9854748 | 0.64 | MTNR1A (0.49) | DRD2DRD4DRD3KCNH2MEN1 | |
| SCHEMBL10459597 | 0.63 | MAOB (0.45) | PPARDPPARG | |
| SCHEMBL5287776 | 0.63 | KCNA3 (0.73) | DRD2DRD4DRD3KCNH2MEN1 | |
| SCHEMBL1171680 | 0.62 | TDP1 (0.69) | DRD2DRD4DRD3KCNH2MEN1 | |
| SCHEMBL1172476 | 0.62 | TDP1 (0.69) | DRD2DRD4DRD3KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |