Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | RRM1 | P23921 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727700 | 0.90 | MTNR1A (0.35) | MTNR1AMTNR1BPTGER1PTGER4PTGER3 | |
| SCHEMBL9727653 | 0.89 | ABCB1 (0.38) | MTNR1AMTNR1BPTGER1PTGER4PTGER3 | |
| SCHEMBL9727762 | 0.82 | NR3C1 (0.38) | AKR1B1ALDH1A1ABCB1HTR1ADRD2 | |
| SCHEMBL9727331 | 0.77 | MTNR1A (0.37) | MTNR1AMTNR1BPTGER1PTGER4PTGER3 | |
| SCHEMBL14552343 | 0.74 | MAOB (0.52) | LTA4HEPHX2PTGER1PTGER4PTGER3 | |
| SCHEMBL9727686 | 0.71 | NR3C1 (0.38) | PTGER1PTGER4PTGER3PTGER2AKR1B1 | |
| SCHEMBL9727488 | 0.71 | ABCB1 (0.43) | LTA4HEPHX2MTNR1AMTNR1BABCB1 | |
| SCHEMBL14435033 | 0.69 | HTR6 (0.43) | LTA4HEPHX2PTGER1PTGER4PTGER3 | |
| SCHEMBL10460139 | 0.69 | LTA4H (0.43) | LTA4HEPHX2MTNR1AMTNR1BPTGER1 | |
| SCHEMBL31561714 | 0.67 | HTR1A (0.69) | LTA4HEPHX2PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |