Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727307 | 0.86 | L3MBTL1 (0.36) | NR3C1AKR1B1ALDH1A1MAPTGAA | |
| SCHEMBL9727725 | 0.84 | AKR1B1 (0.32) | NR3C1AKR1B1ALDH1A1MAPTGAA | |
| SCHEMBL9727762 | 0.82 | NR3C1 (0.38) | NR3C1AKR1B1ALDH1A1MAPTGAA | |
| SCHEMBL9727633 | 0.71 | LTA4H (0.38) | NR3C1AKR1B1ALDH1A1PTGER1PTGER4 | |
| SCHEMBL9727777 | 0.71 | AKR1B1 (0.35) | AKR1B1ALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL14552348 | 0.71 | MAOB (0.54) | ALDH1A1MAPTGAAHPGDTDP1 | |
| SCHEMBL9727331 | 0.67 | MTNR1A (0.37) | AKR1B1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9727671 | 0.67 | MAOB (0.46) | HIF1A | |
| SCHEMBL9727700 | 0.65 | MTNR1A (0.35) | AKR1B1MAPTTDP1L3MBTL1PTGER1 | |
| SCHEMBL9727653 | 0.65 | ABCB1 (0.38) | PTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |